玻璃体液导水率的测量
MEASUREMENT OF THE HYDRAULIC CONDUCTIVITY OF THE VITREOUS HUMOR.
作者信息
Penkova Anita N, Zhang Shuqi, Humayun Mark S, Fraser Scott, Moats Rex, Singh Sadhal Satwindar
机构信息
Department of Aerospace & Mechanical Engineering, University of Southern California, USC Viterbi School of Engineering, Los Angeles, CA 90089-1453.
Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA 90027.
出版信息
J Porous Media. 2020;23(2):195-206. doi: 10.1615/JPorMedia.2020028229.
The hydraulic conductivity of the vitreous humor has been measured for the bovine eye. The experiment was carried out by placing it within upright cylindrical chamber, open at both ends, and letting its liquid content drain out of the bottom opening by gravity, through a 20m nylon mesh filter. Additional negative pressure was provided at the exit by a hanging drainage tube. The diminishing vitreous volume was measured in terms of the height in the chamber and recorded as a function of time. The reduction in the vitreous liquid content also caused the hydraulic conductivity to reduce and this parameter was quantified on the basis of previously-developed theories of fibrous porous media that have been very well established. A theoretical model with a fully analytical expression for the vitreous volume undergoing drainage was developed and used as a least-squares best fit to deliver the initial hydraulic conductivity value of /=(7.8 ± 3.1) × 10 m (Pa-s). The measurements were made with the hyaloid membrane intact and therefore represents an effective conductivity for the entire system, including possible variations within the vitreous.
已对牛眼玻璃体液的水力传导率进行了测量。实验通过将牛眼置于两端开口的直立圆柱形腔室中进行，让其液体内容物通过重力从底部开口排出，经过一个20微米的尼龙网过滤器。通过悬挂的引流管在出口处施加额外的负压。根据腔室内的高度测量逐渐减少的玻璃体液体积，并将其记录为时间的函数。玻璃体液含量的减少也导致水力传导率降低，并且该参数是根据先前已充分确立的纤维多孔介质理论进行量化的。开发了一个具有完全解析表达式的理论模型，用于描述玻璃体液排出过程中的体积变化，并将其用作最小二乘最佳拟合，以得出初始水力传导率值为 /=(7.8 ± 3.1) × 10⁻⁵ m²/(Pa·s)。这些测量是在完整的玻璃体膜情况下进行的，因此代表了整个系统的有效传导率，包括玻璃体内可能存在的变化。
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