Tumolo Alexis Z, Nguyen Duy T
Division of Cardiac Electrophysiology, University of Colorado School of Medicine, Aurora, CO.
J Innov Card Rhythm Manag. 2017 Jul 15;8(7):2774-2783. doi: 10.19102/icrm.2017.080701. eCollection 2017 Jul.
A wide spectrum of cardiac arrhythmias has been observed in patients with isolated ventricular non-compaction, which is defined by hypertrabeculated ventricular myocardium with deep intertrabecular recesses, in the absence of concomitant congenital heart disease. In this genetically diverse phenotype, the development of fibrosis contributes to an arrhythmogenic substrate underlying atrioventricular conduction diseases, supraventricular tachycardias and ventricular tachycardias. Within this spectrum, monomorphic ventricular tachycardia is the most frequently observed arrhythmia, and this prevalence has important implications for sudden cardiac death risk.
在孤立性心室肌致密化不全患者中观察到了广泛的心律失常，孤立性心室肌致密化不全的定义是心室心肌小梁增多且小梁间有深凹，同时不存在先天性心脏病。在这种基因多样的表型中，纤维化的发展促成了房室传导疾病、室上性心动过速和室性心动过速的致心律失常基质。在这个范围内，单形性室性心动过速是最常观察到的心律失常，这种患病率对心脏性猝死风险具有重要意义。
