大鼠反复给予甲基苯丙胺后自受体对多巴胺释放的调节：一项脑内透析研究
Regulation of dopamine release by the autoreceptor after repeated methamphetamine treatment in rats: an intracerebral dialysis study.
作者信息
Kazahaya Y, Hamamura T, Otsuki S
机构信息
Department of Neuropsychiatry, Okayama University Medical School, Japan.
出版信息
Jpn J Psychiatry Neurol. 1988 Dec;42(4):839-43. doi: 10.1111/j.1440-1819.1988.tb01173.x.
Abstract
A group of rats received intraperitoneal injections of methamphetamine (MAP) once a day for 14 days. Seven days after the last injection, the striatal dopamine efflux and its inhibition by a low dose (100 micrograms/kg) of apomorphine were examined by in vivo intracerebral dialysis. The extent of inhibition was not altered after the MAP pretreatment, which does not suggest the presence of subsensitivity of dopamine auto-receptors.
摘要
一组大鼠每天接受一次腹腔注射甲基苯丙胺（MAP），持续14天。在最后一次注射后7天，通过体内脑透析检查纹状体多巴胺外流及其对低剂量（100微克/千克）阿扑吗啡的抑制作用。MAP预处理后抑制程度未改变，这并不表明多巴胺自身受体存在敏感性降低。
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