Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia.
Novosibirsk State Medical University, Ministry of Health of the Russian Federation, Novosibirsk, Russia.
Bull Exp Biol Med. 2020 May;169(1):100-103. doi: 10.1007/s10517-020-04833-6. Epub 2020 Jun 3.
Examination of collagen turnover in the liver, lungs, and spleen of BALB/c mice revealed the age-related differences in the levels of hydroxyproline and its fractions. The highest level of total hydroxyproline was observed in the lungs and spleen of young (2-month-old) mice. In the liver, this level attained maximum at the age of 6 months at the expense of elevation of protein-bound hydroxyproline relatively its level in 2-month-old mice. At the age of 12 months, the levels of total hydroxyproline in the liver and spleen were lower than in 6-month-old mice. The decrease in the collagen turnover rate in the liver of 12-month-old mice reflected lower levels of hydroxyproline fractions in comparison with the corresponding values in 6-month-old mice. The rates of collagen turnover in organs differed in mice of different ages: it was maximum in the lungs and spleen of young animals and in the liver of middle-aged mice.
检测 BALB/c 小鼠肝脏、肺脏和脾脏中的胶原蛋白代谢发现，羟脯氨酸及其各组分的水平随年龄而变化。在幼鼠（2 月龄）中，总羟脯氨酸水平最高，出现在肺脏和脾脏中。在肝脏中，其水平在 6 月龄时达到最高，此时蛋白结合羟脯氨酸水平相对于 2 月龄时升高。12 月龄时，肝脏和脾脏中的总羟脯氨酸水平低于 6 月龄时。12 月龄时，与 6 月龄小鼠相比，肝脏胶原蛋白周转率降低，反映出羟脯氨酸各组分水平降低。不同年龄的小鼠其器官胶原蛋白周转率不同：在幼龄动物的肺脏和脾脏以及中年动物的肝脏中达到最高。
