Belobragina G V, Medvedev L A
Vopr Med Khim. 1978 Jan-Feb;24(1):123-6.
Content of soluble and insoluble collagen, glycosamine glycans, glycoproteins, lipids and nucleic acids was studied in rat lungs during postnatal ontogenesis (up to 32 months). Three age groups of animals, corresponding to juvenile, mature and old age, were used. Intensive collagenoformation and high content of soluble collagen fraction were found in animals of juvenile age. Mature age was characterized by static equilibrium between soluble and insoluble collagen fractions as well as by stabilization in concentration of RNA, hexuronic acids, hexoses, tyrosine, sialic acids and total lipids. Decrease of DNA concentration with simultaneous increase in phospholipid content preceded in ageing the alteration in collagen composition - elevation in insoluble and loss of soluble its fractions. At the ageing period content of glycosamines was relatively decreased but concentration of other substances varied slightly.
研究了出生后个体发育过程中（直至32个月）大鼠肺中可溶性和不溶性胶原蛋白、氨基聚糖、糖蛋白、脂质和核酸的含量。使用了对应幼年、成年和老年的三个年龄组动物。在幼年动物中发现了强烈的胶原形成和高含量的可溶性胶原组分。成年期的特征是可溶性和不溶性胶原组分之间的静态平衡以及RNA、己糖醛酸、己糖、酪氨酸、唾液酸和总脂质浓度的稳定。在衰老过程中，DNA浓度降低，同时磷脂含量增加，这先于胶原蛋白组成的改变——不溶性胶原蛋白增加，可溶性胶原蛋白组分减少。在衰老期，氨基聚糖的含量相对降低，但其他物质的浓度变化不大。
