Department of Biophysics, Faculty of Medicine, Bolu Abant Izzet Baysal University, 14030, Bolu, Turkey.
Department of Biophysics, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.
Environ Sci Pollut Res Int. 2020 Sep;27(25):31543-31554. doi: 10.1007/s11356-020-09401-z. Epub 2020 Jun 3.
In this study, we evaluated the possible effects of sequenced pulsed magnetic fields (PMF) of 1-mT treatments with designed different frequencies (PMF-1-1, 3, 5, 7 Hz or PMF-2-7, 9, 12, 14 Hz) on the inflammatory signs such as abnormal pain behaviors, hyperalgesia and allodynia, edema, and fever in carrageenan (CG)-induced hind paw inflammation model in rats. Paw tissues were also histologically examined. PMF exposure was applied 3 times in 24 h. CG injection gradually decreased the thermal latencies and mechanical threshold and caused significant increases in temperature and mass of paw. PMF treatments significantly reduced the temperature and mass in the paw of rats with inflammation. PMF-1 treatments caused significant increases in the latencies and thresholds. However, administration of PMF-2 treatment was significantly decreased the latency and threshold. Furthermore, the histological pieces of evidence also suggested the anti-inflammatory effects of PMF-1 treatments or inflammatory actions of PMF-2 treatments. Findings presented in this paper suggest that 1-mT PMF treatments may have anti-edematous and antipyretics activities in inflamed rats. However, the effects of PMF treatments on abnormal pain hypersensitivities may be different. PMF treatments may make inflammatory pain relief or worse in inflamed rats depending on the PMF frequencies in sequence.
在这项研究中，我们评估了设计不同频率（PMF-1-1、3、5、7 Hz 或 PMF-2-7、9、12、14 Hz）的序列脉冲磁场（PMF）1 mT 处理对炎症迹象的可能影响，如异常疼痛行为、痛觉过敏和感觉异常、水肿和发热在大鼠角叉菜胶（CG）诱导的后爪炎症模型中。还对爪组织进行了组织学检查。PMF 暴露在 24 小时内进行了 3 次。CG 注射逐渐降低了热潜伏期和机械阈值，并导致爪子温度和质量显著增加。PMF 治疗显著降低了炎症大鼠爪子的温度和质量。PMF-1 治疗导致潜伏期和阈值显著增加。然而，PMF-2 治疗的给药显著降低了潜伏期和阈值。此外，组织学证据也表明 PMF-1 治疗具有抗炎作用或 PMF-2 治疗具有炎症作用。本文提出的研究结果表明，1 mT PMF 治疗可能对炎症大鼠具有抗水肿和退热作用。然而，PMF 治疗对异常疼痛敏感性的影响可能不同。PMF 治疗可能会根据序列中 PMF 的频率使炎症大鼠的炎性疼痛缓解或恶化。
