Chen Ling, Cheng Zhi-Qiang, Liu Fang, Xia Yang, Chen Yong-Gang
Department of Pharmacy, Wuhan Third Hospital (Tongren Hospital of Wuhan University) Wuhan 430060, China.
Chinese Medicine Integrative Oncology Department, China-Japan Friendship Hospital Beijing 100029, China.
Zhongguo Zhong Yao Za Zhi. 2020 May;45(10):2232-2238. doi: 10.19540/j.cnki.cjcmm.20200322.505.
In this study, Donghua Hospital information management system and Meikang clinical pharmacy management system were used to collect medical records of all inpatients diagnosed as coronavirus disease 2019(COVID-19) in Wuhan Third Hospital. The statistics was based on the data of the cases treated with Ganlu Xiaodu Decoction, including demographic statistics, clinical cha-racteristics before medication, outcome of after medication and efficacy of drug combination. Excel 2003 and SPSS Clementine 12.0 software were used to conduct statistics on the included cases, and Apriori algorithm and association rules were used for the association analysis on drug combination. A total of 131 cases of COVID-19 were treated with Ganlu Xiaodu Decoction combined with Chinese and Western medicine. All of the patients were cured and discharged. The drug combination mainly included Ganlu Xiaodu Decoction, abidor, Lianhua Qingwen, moxifloxacin, Qiangli Pipa Lu, vitamin C, glycyrrhizinate diammonium, pantoprazole and Shufeng Jiedu. There is a certain regularity and effectiveness in the treatment of COVID-19 infection patients with the combination of Ganlu Xiaodu Decoction and other drugs, but the rationality and safety still need to be further verified.
本研究采用东华医院信息管理系统和美康临床药学管理系统，收集武汉第三医院所有确诊为新型冠状病毒肺炎（COVID-19）的住院患者病历。统计以甘露消毒丹治疗的病例数据为基础，包括人口统计学统计、用药前临床特征、用药后转归及药物联用疗效。使用Excel 2003和SPSS Clementine 12.0软件对纳入病例进行统计，并采用Apriori算法和关联规则对药物联用进行关联分析。共有131例COVID-19患者采用甘露消毒丹联合中西医药物治疗。所有患者均治愈出院。药物联用主要包括甘露消毒丹、阿比多尔、连花清瘟、莫西沙星、强力枇杷露、维生素C、甘草酸二铵、泮托拉唑及疏风解毒。甘露消毒丹与其他药物联用治疗COVID-19感染患者有一定的规律性和有效性，但合理性及安全性仍需进一步验证。
