Gao Yang, Wang Gui-Qian, Xie Yan-Ming, Wei Rui-Li, Liu Fu-Mei
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences Beijing 100700, China.
Beijing Hospital of Traditional Chinese Medicine, Capital Medical University Beijing 100010, China.
Zhongguo Zhong Yao Za Zhi. 2020 May;45(10):2304-2309. doi: 10.19540/j.cnki.cjcmm.20200211.504.
Guizhi Fuling Capsules is a new-type traditional Chinese medicine preparation made by modern process method. It was widely used to treat uterine fibroids, pelvic inflammation, dysmenorrhea, endometriosis, mammary gland hyperplasia and other gynecological diseases. Under the combination of disease and syndrome, the diagnosis and treatment model of "Yizheng Tongbing, Yibing Tongzhi" with Chinese patent medicine has been widely used in clinical practice. Meanwhile, the effectiveness and safety have been given more and more attention. Based on the effectiveness of Guizhi Fuling Capsules, this paper preliminarily summarized the dominant diseases in randomized controlled trials and systematic reviews of Guizhi Fuling Capsules. On the basis of the basic theory of traditional Chinese medicine and modern pharmacological mechanism, the clinical efficacy and mechanism of Guizhi Fuling Capsules were explored. Finally, according to the traditional Chinese medicine theory of "Yizheng Tongbing, Yibing Tongzhi", all the clinical evidences were integrated to form an integrated evidence chain, so as to provide guidance for the safe and rational use of Guizhi Fuling Capsules.
桂枝茯苓胶囊是采用现代工艺方法制成的新型中药制剂。它被广泛用于治疗子宫肌瘤、盆腔炎、痛经、子宫内膜异位症、乳腺增生等妇科疾病。在病证结合的情况下，中成药“异病同治，同病异治”的诊疗模式已在临床实践中广泛应用。同时，其有效性和安全性也越来越受到关注。基于桂枝茯苓胶囊的有效性，本文初步总结了桂枝茯苓胶囊随机对照试验和系统评价中的优势病种。在中医基础理论和现代药理机制的基础上，探讨了桂枝茯苓胶囊的临床疗效及作用机制。最后，根据中医“异病同治，同病异治”理论，整合所有临床证据形成完整的证据链，为桂枝茯苓胶囊的安全合理应用提供指导。
