Division of Urology-Fleury Group, Universidade Federal de Sao Paulo, Sao Paulo, Brazil.
Division of Molecular Biology, Department of Gynecology-Fleury Group, Universidade Federal de Sao Paulo, Sao Paulo, Brazil.
Diagn Cytopathol. 2020 Nov;48(11):1021-1026. doi: 10.1002/dc.24518. Epub 2020 Jun 4.
To explore male human papillomavirus (HPV) contemporary genotyping epidemiology and correlations to peniscopy, cytology, and histopatology.
Medical records of patients who had been submitted to HPV infection screening with genotyping, peniscopy, cytology, and histopathology in a period of 2 years were reviewed. Frequency analysis and correlations between the diagnostic tools were established.
Genotype of 1132 men resulted in 69.2% (784) positivity for HPV DNA, 78% classified as high risk of oncogenesis. Co-infections occurred in 429 (54.7%) and the most frequently identified types were HPV-6, HPV-42, and HPV-16, in 133 (17%), 94 (12%), and 86 (11%) patients, respectively. Positive/negative predictive values of peniscopy, cytology, and histopathology were 83/31%, 92/32%, and 87/33%, respectively. As a result, though significant, the correlations between genotype and non-molecular tests were poor.
In the current contemporary representative male cohort, over two thirds are positive for human HPV DNA, 78% of high risk and with over half co-infections. Though significant, its correlation with non-molecular tests is poor and while the positive predictive values of peniscopy, cytology, and histopatology are between 83% and 92%, their negative predictive values are as low as 31% to 33%.
探索男性人乳头瘤病毒（HPV）的当代基因分型流行病学及其与阴茎镜检查、细胞学和组织病理学的相关性。
对 2 年内接受 HPV 感染筛查并进行基因分型、阴茎镜检查、细胞学和组织病理学检查的患者的病历进行了回顾性分析。建立了频率分析和诊断工具之间的相关性。
1132 名男性的基因型结果显示，HPV DNA 阳性率为 69.2%（784 例），78%被归类为致癌风险高。共感染发生在 429 例（54.7%）中，最常见的类型是 HPV-6、HPV-42 和 HPV-16，分别在 133 例（17%）、94 例（12%）和 86 例（11%）患者中检出。阴茎镜检查、细胞学和组织病理学的阳性/阴性预测值分别为 83/31%、92/32%和 87/33%。因此，尽管有显著相关性，但基因型与非分子检测之间的相关性较差。
在当前具有代表性的当代男性队列中，超过三分之二的人 HPV DNA 阳性，78%为高危型，且超过一半存在共感染。尽管有显著相关性，但与非分子检测的相关性较差，而阴茎镜检查、细胞学和组织病理学的阳性预测值在 83%至 92%之间，但阴性预测值低至 31%至 33%。
