Machado Roberto Dias, Faria Eliney Ferreira, Júnior Antonio Antunes Rodrigues, Stirpari Filipe, Feres Rafael Neuppmann, Spiess Philippe E, Shariat Shahrokh F, Reis Leonardo Oliveira, Dos Reis Rodolfo Borges
Barretos Cancer Hospital, Barretos, SP, Brazil.
Medicine School of Ribeirão Preto, University of São Paulo, São Paulo, SP, Brazil.
BMC Cancer. 2025 Mar 4;25(1):394. doi: 10.1186/s12885-025-13763-3.
Obese patients with penile cancer may have more advanced disease. This study evaluated the association of obesity with penile cancer and the risk of lymph node metastases in patients who underwent inguinal lymphadenectomy.
We retrospectively reviewed the charts of 197 penile cancer (PC) patients from January 2000 to December 2011. Seventy underwent inguinal lymphadenectomy. For this subgroup, chi-square analysis evaluated the correlations of sociodemographic, clinical, and pathological variables with the presence of positive inguinal lymph nodes. Patients were divided into normal weight, overweight, and obese categories according to body mass index (BMI). The mean numbers of positive and resected lymph nodes were compared for each BMI category.
The percentage of overweight men in the Brazilian population and among patients with PC was 52.6% and 42.8%, respectively. For patients who underwent lymphadenectomy, the mean BMIs were 25.9 ± 6. Most patients were white, married, had a lower education level, and had no history of smoking. Partial penectomy was the most frequently performed surgery; lymphovascular invasion occurred in 45.7%, and lymph node metastasis occurred in 52.9% of cases. The mean numbers of resected and positive lymph nodes for normal weight, overweight, and obesity were 21.1 and 2.2, 23.3 and 2.2, and 16.8 and 1.5, respectively.
Overweight and obesity were less frequently seen in patients with PC than in the Brazilian population. BMI was not a risk factor for developing lymph node metastasis; the only predictive factor for lymph node metastasis was the presence of lymphovascular invasion.
肥胖的阴茎癌患者可能患有更晚期的疾病。本研究评估了肥胖与阴茎癌的关联以及接受腹股沟淋巴结清扫术患者的淋巴结转移风险。
我们回顾性分析了2000年1月至2011年12月期间197例阴茎癌（PC）患者的病历。其中70例接受了腹股沟淋巴结清扫术。对于该亚组，采用卡方分析评估社会人口统计学、临床和病理变量与腹股沟淋巴结阳性之间的相关性。根据体重指数（BMI）将患者分为正常体重、超重和肥胖类别。比较每个BMI类别中阳性和切除淋巴结的平均数量。
巴西人群和PC患者中超重男性的比例分别为52.6%和42.8%。接受淋巴结清扫术的患者，平均BMI为25.9±6。大多数患者为白人、已婚、教育水平较低且无吸烟史。部分阴茎切除术是最常实施的手术；45.7%的病例发生淋巴血管侵犯，52.9%的病例发生淋巴结转移。正常体重、超重和肥胖患者切除淋巴结和阳性淋巴结的平均数量分别为21.1和2.2、23.3和2.2、16.8和1.5。
与巴西人群相比，PC患者中超重和肥胖的情况较少见。BMI不是发生淋巴结转移的危险因素；淋巴结转移的唯一预测因素是淋巴血管侵犯的存在。
