Paratrimerin I, cytotoxic acridone alkaloid from the roots of .

Bioactivity-guided fractionation of the CHCl-soluble extract of the roots of was carried out to obtain a new acridone alkaloid, paratrimerin I. Its structure was elucidated based on NMR spectroscopic data interpretation. Paratrimerin I showed noteworthy cytotoxicity against the HepG2 human hepatocellular and MCF-7 human breast carcinoma cell lines, with the submicromolar IC values of 0.43 and 0.26 M, respectively. The -methyl, C-4 methoxy, and C-5 hydroxy groups in the acridone skeleton can be proposed as a structural feature for good cytotoxicity.