Liu Hao, Luo Yi, Zhang Jing, Liu Man, Dong Lin
Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Org Lett. 2020 Jun 19;22(12):4648-4652. doi: 10.1021/acs.orglett.0c01415. Epub 2020 Jun 4.
Modification of BINOL units has been well examined via Rh-catalyzed C-H activation and functionalization reactions by using ester carbonyls as directing groups and alkenes as coupling partners. The one-pot strategy was an efficient protocol for the rapid synthesis of BINOL derivatives with retention of optical purity.
通过使用酯羰基作为导向基团、烯烃作为偶联伙伴，经由铑催化的C-H活化和官能化反应，对联萘酚（BINOL）单元的修饰已得到充分研究。一锅法策略是一种高效的方案，可用于快速合成具有光学纯度保留的联萘酚衍生物。
