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ELAPE 相较于 APR 的短期优势。

Short-term advantages of ELAPE over APR.

机构信息

Surgical-Oncosurgical Department, Uzsoki Teaching Hospital, Budapest, Hungary.

出版信息

Acta Chir Belg. 2021 Oct;121(5):327-332. doi: 10.1080/00015458.2020.1778265. Epub 2020 Jun 12.

Abstract

INTRODUCTION

Conventional abdominoperineal resection (APR) has a high rate of local recurrence. Extralevator abdominoperineal excision (ELAPE) can potentially diminish the rate of intraoperative tumour perforation (IOTP) and can provide wider circumferential resection margins (CRM) but at the price of higher perineal complication rate. The aim of our study was to compare the short term results of conventional APR to ELAPE.

MATERIALS AND METHODS

Thirty-five consecutively operated APRs compared to 38 also consecutively operated ELAPEs. Prospectively collected short-term outcome data were analysed retrospectively.

RESULTS

There was no difference in demographics, disease stage or tumour location between groups. IOTP rate and CRM positivity rates were similar between the two groups ( = .608). No difference was found in major (Clavien-Dindo III-V) complications, but we found statistically significant difference in minor (Clavien-Dindo I-II) complications ( = .01) in favour of the ELAPE group. Frequency of perineal SSI was lower in ELAPE group, but the difference was not significant ( = .320). Intraoperative iatrogenic complications occurred at significantly lower rate in ELAPE group ( = .035). Also, postoperative morbidity connected with the dissection in the perineal phase (e.g. urine incontinence, urinary retention) was significantly lower ( = .018) after ELAPE.

DISCUSSION AND CONCLUSIONS

In our experience ELAPE operations may diminish the rate of Clavien-Dindo I-II complications compared to conventional APR. This effect is ensuing from the decrease of intraoperative iatrogenic complications and from the decrease of minor postoperative complications.

摘要

简介

传统的经腹会阴切除术(APR)局部复发率较高。经肛提肌外腹会阴切除术(ELAPE)可降低术中肿瘤穿孔(IOTP)的发生率,并提供更广泛的环周切缘(CRM),但会增加会阴并发症的发生率。本研究旨在比较传统 APR 与 ELAPE 的短期结果。

材料与方法

连续 35 例 APR 与连续 38 例 ELAPE 进行比较。回顾性分析前瞻性收集的短期结果数据。

结果

两组患者在人口统计学、疾病分期或肿瘤位置方面无差异。两组的 IOTP 发生率和 CRM 阳性率相似(=0.608)。两组在主要(Clavien-Dindo III-V)并发症方面无差异,但在次要(Clavien-Dindo I-II)并发症方面存在统计学差异(=0.01),ELAPE 组的并发症发生率较低。ELAPE 组的会阴部位手术部位感染(SSI)发生率较低,但差异无统计学意义(=0.320)。ELAPE 组术中医源性并发症发生率显著降低(=0.035)。此外,ELAPE 后与会阴切开术相关的术后发病率(如尿失禁、尿潴留)显著降低(=0.018)。

讨论与结论

根据我们的经验,ELAPE 手术可能会降低 Clavien-Dindo I-II 并发症的发生率,与传统 APR 相比。这种效果是由于术中医源性并发症的减少和术后轻微并发症的减少而产生的。

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