Tecnologico de Monterrey, Campus Toluca, Toluca de Lerdo, Mexico.
Unidad Profesional Interdisciplinaria de Biotecnología, Instituto Politécnico Nacional, México City, México.
Crit Rev Food Sci Nutr. 2021;61(13):2152-2174. doi: 10.1080/10408398.2020.1772717. Epub 2020 Jun 4.
Steviol glycosides (SGs), as natural sweeteners from , are currently employed for replacing sugar and its derivatives in several food products and formulations. Such compounds play an essential role in human health. Their usage provides a positive effect on preventing diseases related to sugar consumption, including diabetes mellitus, cancer, and lipid metabolism disorders. The traditional extraction of SGs is performed by means of solvent extraction, which limits their application since the removal of residual solvents is a challenging task requiring further downstream purification steps. In addition, the presence of residual solvents negatively affects the quality of such compounds. Today, food technicians are looking for innovative and improved techniques for the extraction, recovery and purification of SGs. Membrane-based technologies, including microfiltration, ultrafiltration, and nanofiltration, have long been proven to be a valid alternative for efficient extraction and purification of several high added-value molecules from natural sources. Such processes and their possible coupling in integrated membrane systems have been successfully involved in recovery protocols of several compounds, such as metabolites, polyphenols, anthocyanins, natural pigments, proteins, from different sources (e.g., agro-food wastes, plant extracts, fruits, fermentation broths, among others). Herein, we aim to review the current progresses and developments about the extraction of SGs with membrane operations. Our attention has been paid to the latest insights in the field. Furthermore, key process parameters influencing the extraction and purification of SGs are also discussed in detail.
甜菊糖苷（SGs）是 的天然甜味剂，目前被用于替代糖及其衍生物在多种食品产品和配方中的应用。这些化合物在人类健康中起着重要作用。它们的使用对预防与糖消费相关的疾病有积极影响，包括糖尿病、癌症和脂质代谢紊乱。SGs 的传统提取方法是溶剂萃取，但由于去除残留溶剂是一项具有挑战性的任务，需要进一步的下游纯化步骤，因此限制了其应用。此外，残留溶剂的存在会对这些化合物的质量产生负面影响。如今，食品技术人员正在寻找创新和改进的技术，用于提取、回收和纯化 SGs。膜基技术，包括微滤、超滤和纳滤，长期以来一直被证明是从天然资源中高效提取和纯化多种高附加值分子的有效替代方法。这些过程及其在集成膜系统中的可能耦合已成功应用于从不同来源（如农业食品废物、植物提取物、水果、发酵液等）中回收多种化合物（如代谢物、多酚、花青素、天然色素、蛋白质）的回收方案中。本文旨在综述膜操作提取 SGs 的最新进展和发展。我们关注该领域的最新研究进展。此外，还详细讨论了影响 SGs 提取和纯化的关键工艺参数。
