Department of Biostatistics, Medicine, Bursa Uludag University , Bursa, Turkey.
Department of Neurology, Bursa Yuksek Ihtisas Education and Training Hospital, University of Health Sciences , Bursa, Turkey.
Neurol Res. 2020 Sep;42(9):760-766. doi: 10.1080/01616412.2020.1773631. Epub 2020 Jun 4.
In this study we aimed to investigate corpus callosum shape differences between restless leg syndrome patients and healthy controls, and to determine whether disease severity and duration are indicators for corpus callosum deformation in RLS patients.
This study was conducted using the magnetic resonance imaging scans of 33 restless leg syndrome patients and 33 control subjects. Landmarks were marked on the digital images and callosal landmark coordinate data were used to assess shape difference by performing Generalized Procrustes analysis. The shape deformation from controls to the patients was evaluated performing the Thin Plate Spline approach.
There was a statistically significant shape difference between the groups. Highest deformation was determined at the posterior midbody of the corpus callosum. Growth curve analyses showed that with the increase in disease duration and severity, the CC size decreased.
The present study demonstrated callosal shape differences in restless leg syndrome using a landmark-based geometric morphometric approach, considering the topographic distribution of corpus callosum for the first time.
本研究旨在探讨不宁腿综合征患者与健康对照者之间胼胝体形状的差异，并确定疾病严重程度和持续时间是否是 RLS 患者胼胝体变形的指标。
本研究使用了 33 名不宁腿综合征患者和 33 名对照者的磁共振成像扫描。在数字图像上标记标志点，并通过广义 Procrustes 分析评估形状差异。通过薄板样条法评估从对照组到患者的形状变形。
两组之间存在统计学上的显著形状差异。胼胝体中部后段的变形最大。生长曲线分析表明，随着疾病持续时间和严重程度的增加，CC 大小减小。
本研究采用基于标志点的几何形态测量方法，首次考虑了胼胝体的地形分布，证明了不宁腿综合征的胼胝体形状差异。
