Institute of Medical Science, University of Toronto, Toronto, Canada.
Department of Diagnostic Imaging, The Hospital for Sick Children, University of Toronto, Toronto, Canada.
Haemophilia. 2020 Jul;26(4):565-574. doi: 10.1111/hae.14032. Epub 2020 Jun 4.
A goal of the International Prophylaxis Study Group (IPSG) is to provide an accurate instrument to measure MRI-based disease severity of haemophilic arthropathy at various time points, so that longitudinal changes in disease severity can be identified to support decisions on treatment management. We review and discuss in this paper the evaluative purpose of the IPSG MRI scale in relation to its development and validation processes so far. We also critically appraise the validity, reliability and responsiveness of using the IPSG MRI scale in different clinical and research settings, and whenever applicable, compare these clinimetric properties of the IPSG MRI scale with those of its precursors, the compatible additive and progressive MRI scales.
国际预防研究组（IPSG）的目标之一是提供一种准确的工具，以测量不同时间点基于 MRI 的血友病性关节病的严重程度，从而识别疾病严重程度的纵向变化，以支持治疗管理决策。我们在本文中回顾和讨论了 IPSG MRI 量表的评估目的，以及迄今为止的开发和验证过程。我们还批判性地评估了在不同临床和研究环境中使用 IPSG MRI 量表的有效性、可靠性和反应性，并且在适用的情况下，将 IPSG MRI 量表的这些临床计量特性与其前身，即相容的附加和渐进性 MRI 量表进行比较。
