Wei Zhihao, Ou Lijun, Chai Sheng, Zhang Dongdong, Tang Gangjian
Guilin Municipal Hospital of Traditional Chinese Medicine, Guilin, Guangxi, China.
Front Med (Lausanne). 2025 Apr 16;12:1556906. doi: 10.3389/fmed.2025.1556906. eCollection 2025.
Hemophilic arthropathy (HA), a common complication of hemophilia caused by recurrent hemarthrosis, significantly impacts patients' quality of life. Despite ongoing research, a comprehensive overview of research trends for HA is lacking. Therefore, this study utilizes bibliometrics and knowledge mapping techniques to visually analyze the current status and developmental trends of HA-related research, and analyzed and predicted future research hotspots.
A bibliometric analysis was conducted using the Web of Science Core Collection database. Data on publications, author names, countries, research institutions, journals, and keywords were extracted and visualized using Bibliometrix, VOSviewer, and CiteSpaces.
The number of HA-related publications has increased steadily over time. United States was found to be the leading country in terms of publications and international collaborations. HEMOPHILIA was found to be the most influential journal and Hospital Universitario La Paz to be the leading institution conducting HA-related research. Rodriguez-Merchan EC was identified as the most prominent researcher in the field. Keyword analysis identified five main research clusters, namely, quality of life and management, pathogenesis, classification and functional assessment, replacement surgery, and ankle arthritis treatment.
This bibliometric analysis provides a comprehensive overview of the research trends for HA. Future studies must focus on elucidating the underlying mechanisms of HA, developing early diagnostic biomarkers, and exploring personalized treatment strategies to improve patient outcomes. Our study offers valuable insights to researchers to facilitate the identification of emerging trends and prioritization of future research directions.
血友病性关节病（HA）是血友病常见的并发症，由反复关节积血引起，严重影响患者生活质量。尽管研究不断，但缺乏对HA研究趋势的全面概述。因此，本研究利用文献计量学和知识图谱技术，直观分析HA相关研究的现状和发展趋势，并分析和预测未来研究热点。
使用Web of Science核心合集数据库进行文献计量分析。提取关于出版物、作者姓名、国家、研究机构、期刊和关键词的数据，并使用Bibliometrix、VOSviewer和CiteSpaces进行可视化。
HA相关出版物数量随时间稳步增加。美国在出版物和国际合作方面是领先国家。《血友病》被发现是最具影响力的期刊，拉巴斯大学医院是开展HA相关研究的领先机构。罗德里格斯 - 梅尔坎·E·C被确定为该领域最杰出的研究人员。关键词分析确定了五个主要研究集群，即生活质量与管理、发病机制、分类与功能评估、置换手术和踝关节关节炎治疗。
这项文献计量分析全面概述了HA的研究趋势。未来的研究必须专注于阐明HA的潜在机制、开发早期诊断生物标志物以及探索个性化治疗策略以改善患者预后。我们的研究为研究人员提供了有价值的见解，以促进识别新出现的趋势并确定未来研究方向的优先级。
