配体促进的钯催化通过空间 C-H 键活化：经由碳钯化/1,4-钯迁移/C-H 官能化序列。
Ligand-Enabled Palladium-Catalyzed Through-Space C-H Bond Activation via a Carbopalladation/1,4-Pd Migration/C-H Functionalization Sequence.
机构信息
Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, 3001, Leuven, Belgium.
Biomolecular Architecture, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, 3001, Leuven, Belgium.
出版信息
Chemistry. 2020 Nov 6;26(62):14075-14079. doi: 10.1002/chem.202001582. Epub 2020 Oct 5.
We report, herein, a palladium-catalyzed cascade comprising carbopalladation, 1,4-Pd-migration and C(sp )-C(sp ) bond formation to construct a variety of bis-heterocyclic frameworks in a single operational step. The methodology provides a direct approach to introduce an oxadiazole core at a remote location without any functional group obligation, with moderate to good yields.
我们在此报告了一种钯催化的级联反应，包括碳钯化、1,4-Pd-迁移和 C(sp )-C(sp )键形成，可在单个操作步骤中构建各种双杂环骨架。该方法为在无需任何功能基团的情况下在远程位置引入恶二唑核心提供了一种直接的方法，产率中等至良好。
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