ERC Advanced Investigator Grant Research Group at the Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, Mainz, 55128, Germany.
Polymers and Pigments Department, National Research Center, Dokki, Giza, 12622, Egypt.
Biotechnol J. 2020 Dec;15(12):e2000101. doi: 10.1002/biot.202000101. Epub 2020 Jul 1.
Cement is used both as a construction material and for medical applications. Previously, it has been shown that the physiological polymer inorganic polyphosphate (polyP) is morphogenetically active in regeneration of skin, bone, and cartilage. The present study investigates the question if this polymer is also a suitable additive to improve the self-healing capacity not only of construction cement but also of inorganic bone void fillers. For the application in the cement, two different polyP-based amorphous nanoparticles (NP) are prepared, amorphous Ca-polyP NP and amorphous Ca-carbonate (ACC) NP. The particles are integrated into poly(methyl methacrylate) in a concentration ratio of 1:10. This material applied onto Portland cement blocks either by brush application or by blow spinning strongly accelerates the self-healing property of the cement after a 10 day incubation period. Most likely, this process depends on bacteria and their membrane-associated alkaline phosphatase, resulting in the formation of calcite from ACC. In a second approach, polyP is integrated into a calcium-silicate-based cement used in reconstitutive medicine. Subsequently, the cement becomes softer and more elastic. The data show that bioinspired polyP/ACC NP are suitable additives to improve the self-healing of construction cement and to biologize bone cement.
水泥既可用作建筑材料，也可用于医疗应用。此前已经表明，生理聚合物无机多磷酸盐（polyP）在皮肤、骨骼和软骨的再生中具有形态发生活性。本研究探讨了这种聚合物是否也适合作为添加剂，不仅可以提高建筑水泥的自修复能力，还可以提高无机骨空隙填充物的自修复能力。为了在水泥中的应用，制备了两种不同的基于多磷酸盐的无定形纳米颗粒（NP），即无定形 Ca-多磷酸盐 NP 和无定形 Ca-碳酸盐（ACC）NP。将这些颗粒以 1:10 的浓度比整合到聚甲基丙烯酸甲酯中。这种材料通过刷涂或吹纺应用于波特兰水泥块上，在 10 天孵育期后，可显著加速水泥的自修复性能。很可能，这个过程取决于细菌及其膜相关的碱性磷酸酶，导致 ACC 形成方解石。在第二种方法中，将多磷酸盐整合到用于再生医学的钙硅酸盐基水泥中。随后，水泥变得更柔软、更有弹性。数据表明，仿生多磷酸盐/ACC NP 是提高建筑水泥自修复能力和使骨水泥具有生物活性的合适添加剂。
