受体样激酶 MDS1 和 MDS2 促进 SUMM2 介导的免疫。
Receptor-like kinases MDS1 and MDS2 promote SUMM2-mediated immunity.
机构信息
Hunan Provincial Key Laboratory of Phytohormones and Growth Development, College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, 410000, China.
Department of Botany, University of British Columbia, 3529-6270 University Blvd, Vancouver, British Columbia, V6T 1Z4, Canada.
出版信息
J Integr Plant Biol. 2021 Feb;63(2):277-282. doi: 10.1111/jipb.12978. Epub 2020 Jul 3.
Disruption of the MEKK1-MKK1/MKK2-MPK4 kinase cascade leads to activation of immunity mediated by the nucleotide-binding leucine-rich repeat (NLR) immune receptor SUMM2, which monitors the phosphorylation status of CRCK3. Here we report that two receptor-like kinases (RLKs), MDS1, and MDS2, function redundantly to promote SUMM2-mediated immunity. Activation of SUMM2-mediated immunity is dependent on MDS1, and to a less extent on MDS2. MDS1 associates with CRCK3 in planta and can phosphorylate CRCK3 in vitro, suggesting that it may target CRCK3 to positively regulate SUMM2-mediated signaling. Our finding highlights a new defense mechanism where RLKs promote NLR-mediated immunity.
MEKK1-MKK1/MKK2-MPK4 激酶级联的破坏导致核苷酸结合富含亮氨酸重复（NLR）免疫受体 SUMM2 介导的免疫的激活，该受体监测 CRCK3 的磷酸化状态。在这里，我们报告说，两种受体样激酶（RLK），MDS1 和 MDS2，冗余地发挥作用以促进 SUMM2 介导的免疫。SUMM2 介导的免疫的激活依赖于 MDS1，并且在较小程度上依赖于 MDS2。MDS1 在植物体内与 CRCK3 相关联，并且可以体外磷酸化 CRCK3，这表明它可能将 CRCK3 作为靶标以正向调节 SUMM2 介导的信号转导。我们的发现强调了一种新的防御机制，其中 RLK 促进 NLR 介导的免疫。
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