Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Australia; Institute of Immunology and Immunotherapy, University of Birmingham, UK.
Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Australia.
Curr Opin Immunol. 2020 Jun;64:110-116. doi: 10.1016/j.coi.2020.04.007. Epub 2020 Jun 1.
Fibroblastic reticular cells (FRCs) are a necessary immunological component for T cell health. These myofibroblasts are specialized for immune cell support and develop in locations where T and B lymphocyte priming occurs, usually secondary lymphoid organs, but also tertiary lymphoid structures and sites of chronic inflammation. This review describes their dual supportive and suppressive functions and emerging evidence on the co-ordination required to balance these competing roles.
纤维母细胞网状细胞（FRC）是 T 细胞健康所必需的免疫组成部分。这些肌纤维母细胞专门用于免疫细胞支持，并在 T 和 B 淋巴细胞启动发生的部位发育，通常是次级淋巴器官，但也存在于三级淋巴结构和慢性炎症部位。本文描述了它们的双重支持和抑制功能，以及关于协调这些相互竞争的作用所需的新证据。
