Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Trends Immunol. 2021 Aug;42(8):723-734. doi: 10.1016/j.it.2021.06.006. Epub 2021 Jul 10.
Lymph nodes (LNs), where immune responses are initiated, are organized into distinctive compartments by fibroblastic reticular cells (FRCs). FRCs imprint immune responses by supporting LN architecture, recruiting immune cells, coordinating immune cell crosstalk, and presenting antigens. Recent high-resolution transcriptional and histological analyses have enriched our knowledge of LN FRC genetic and spatial heterogeneities. Here, we summarize updated anatomic, phenotypic, and functional identities of FRC subsets, delve into topological and transcriptional remodeling of FRCs in inflammation, and illustrate the crosstalk between FRCs and immune cells. Discussing FRC functions in immunity and tolerance, we highlight state-of-the-art FRC-based therapeutic approaches for maintaining physiological homeostasis, steering protective immunity, inducing transplantation tolerance, and treating diverse immune-related diseases.
淋巴结 (LNs) 是免疫反应起始的部位，其内的成纤维网状细胞 (FRCs) 将其组织成独特的隔室。FRCs 通过支持 LN 结构、招募免疫细胞、协调免疫细胞串扰和呈递抗原来影响免疫反应。最近的高分辨率转录组学和组织学分析丰富了我们对 LN FRC 遗传和空间异质性的认识。在这里，我们总结了 FRC 亚群的更新的解剖学、表型和功能特征，深入探讨了 FRC 在炎症中的拓扑和转录重塑，并阐述了 FRC 与免疫细胞之间的串扰。在讨论 FRC 在免疫和耐受中的功能时，我们重点介绍了基于 FRC 的最新治疗方法，以维持生理稳态、引导保护性免疫、诱导移植耐受以及治疗各种与免疫相关的疾病。
