Department of Psychology, University of Toronto, Toronto, Ontario, Canada.
Department of Psychology, University of Toronto, Toronto, Ontario, Canada.
Neurobiol Aging. 2020 Oct;94:1-6. doi: 10.1016/j.neurobiolaging.2020.04.019. Epub 2020 Apr 29.
Oophorectomy prior to menopause is associated with late-life dementia. Memory decline may start within 6 months after oophorectomy in middle-aged women, suggested by lower verbal and working memory performance. Unknown is whether such changes persist beyond 6 months, and whether they are reversed by estradiol. Short-term benefits of estradiol on verbal memory following oophorectomy were observed in one study, but longer term effects remain unknown. In the present study, middle-aged BRCA1/2 mutation carriers with early oophorectomy at least 1 year prior to study onset were tested on verbal and working memory with results stratified by (1) current estradiol use (n = 22) or (2) no history of estradiol use (n = 24), and compared to age-matched premenopausal controls (n = 25). Both memory abilities were adversely affected by oophorectomy, but only working memory was maintained by estradiol. Estrogen metabolite levels correlated with working memory, suggesting a role for estradiol in preserving this ability. Memory decline appears to persist after early oophorectomy, particularly for women who do not take estradiol.
绝经前卵巢切除术与晚年痴呆有关。中年女性在卵巢切除术后 6 个月内，言语和工作记忆能力下降，提示记忆衰退可能开始。目前尚不清楚这些变化是否会持续 6 个月以上，以及雌激素是否会逆转这些变化。一项研究观察到，卵巢切除术后短期应用雌激素对言语记忆有好处，但长期效果仍不清楚。在本研究中，BRCA1/2 突变携带者在研究开始前至少 1 年前接受了早期卵巢切除术，她们的言语和工作记忆能力在以下情况下进行了测试：（1）当前使用雌激素（n=22）或（2）没有使用过雌激素（n=24），并与年龄匹配的绝经前对照组（n=25）进行了比较。卵巢切除术都会对两种记忆能力产生不利影响，但只有雌激素能维持工作记忆。雌激素代谢物水平与工作记忆相关，表明雌激素在维持这种能力方面发挥作用。记忆衰退似乎在早期卵巢切除术后持续存在，尤其是对于那些不服用雌激素的女性。
