Brown Alana, Gravelsins Laura, Gervais Nicole J, Rieck Jenny, Zhao Sophia, Duchesne Annie, Witt Suzanne T, Kämpe Robin, Olsen Rosanna, Barense Morgan, Classon Elisabet, Theodorsson Elvar, Ernerudh Jan, Åvall-Lundqvist Elisabeth, Kjølhede Preben, Engström Maria, Shao Zhuo, Bernardini Marcus, Jacobson Michelle, Rajah M Natasha, Grady Cheryl, Einstein Gillian
Department of Psychology, University of Toronto, Toronto, Ontario, Canada.
Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, the Netherlands.
Alzheimers Dement. 2025 Feb;21(2):e14447. doi: 10.1002/alz.14447. Epub 2024 Dec 28.
Women with early bilateral salpingo-oophorectomy (BSO) have greater Alzheimer's disease (AD) risk than women with spontaneous menopause (SM), but the pathway toward this risk is understudied. Considering associative memory deficits may reflect early signs of AD, we studied how BSO affected brain activity underlying associative memory.
Early midlife women with BSO (with and without 17β-estradiol therapy [ET]) and age-matched controls (AMCs) with intact ovaries completed a face-name associative memory task during functional magnetic resonance imaging. Hippocampal activity along the anteroposterior axis during associative encoding and retrieval was compared among three groups (BSO [n = 28], BSO+ET [n = 35], AMCs [n = 40]).
Both BSO groups (with and without ET) showed lower posterior hippocampal activation during encoding compared to the AMC group. However, this difference in activation was not significantly correlated with associative memory task performance.
Early 17β-estradiol loss may influence posterior hippocampal activity during associative encoding, possibly presaging late-life AD.
After ovarian removal, changes in hippocampal function may affect dementia risk. Midlife ovarian removal is associated with less activation in the posterior hippocampus. Estradiol therapy may ameliorate alterations in brain function during learning.
早期双侧输卵管卵巢切除术（BSO）的女性患阿尔茨海默病（AD）的风险高于自然绝经（SM）的女性，但导致这种风险的途径尚未得到充分研究。考虑到联想记忆缺陷可能反映了AD的早期迹象，我们研究了BSO如何影响联想记忆背后的大脑活动。
患有BSO（接受和未接受17β-雌二醇治疗[ET]）的中年早期女性以及年龄匹配的卵巢完整的对照者（AMC）在功能磁共振成像期间完成了一项面孔-名字联想记忆任务。比较了三组（BSO组[n = 28]、BSO+ET组[n = 35]、AMC组[n = 40]）在联想编码和检索过程中沿前后轴的海马活动。
与AMC组相比，两个BSO组（接受和未接受ET）在编码过程中后海马激活均较低。然而，这种激活差异与联想记忆任务表现无显著相关性。
早期17β-雌二醇丧失可能影响联想编码过程中的后海马活动，可能预示着晚年AD。
卵巢切除后，海马功能的变化可能影响痴呆风险。中年卵巢切除与后海马激活减少有关。雌二醇治疗可能改善学习过程中脑功能的改变。
