Han Zongqiang, Zhou Lu, Liu Rui, Feng Linlin
Beijing Xiaotangshan Hospital Medical Laboratory, Beijing 102211, China.
Department of Nephrology, Tangdu Hospital, Second Affiliated Hospital of Air Force Military Medical University, Xi'an 710000, China.
Ann Palliat Med. 2020 May;9(3):1134-1143. doi: 10.21037/apm-20-992.
In recent years, the concentration of magnesium in dialysis patients has drawn an increasing amount of attention. Both hemodialysis and peritoneal dialysis may affect magnesium metabolism, but studies in this area are very limited. This study aimed to investigate the serum magnesium concentrations in hemodialysis patients and examine the factors related to the serum magnesium concentration, and to explore the effect of hemodialysis with conventional hemodialysis solution (magnesium ion concentration 0.5 mmol/L) on blood magnesium concentration.
In this single-center, retrospective study, linear regression models were established to explore the factors related to serum magnesium concentration in hemodialysis patients. Serum magnesium concentration was also compared before and after hemodialysis treatment.
The data of 148 hemodialysis patients were collected and analyzed. The mean value of pre-hemodialysis total serum magnesium concentration was 1.11±0.14 mmol/L. The prevalence of hypermagnesemia was 73.65%, and 2 patients had hypomagnesemia (1.35%). Data analysis indicated that total platelet count, serum phosphorus level, serum creatinine, plasma albumin, and total serum cholesterol level were significantly related to serum magnesium concentration. After hemodialysis treatment, the serum magnesium concentration was significantly lower when conventional hemodialysis was used. After hemodialysis, the average decrease in the serum magnesium concentration was 0.14 mmol/L.
Most patients who received hemodialysis had mild hypermagnesemia when routine dialysate was supplied. Serum magnesium concentration is related to patients' nutritional status. Hemodialysis treatment can decrease the total serum magnesium concentration.
近年来，透析患者体内镁的浓度越来越受到关注。血液透析和腹膜透析都可能影响镁的代谢，但该领域的研究非常有限。本研究旨在调查血液透析患者的血清镁浓度，检查与血清镁浓度相关的因素，并探讨使用常规血液透析液（镁离子浓度0.5 mmol/L）进行血液透析对血镁浓度的影响。
在这项单中心回顾性研究中，建立线性回归模型以探讨血液透析患者血清镁浓度的相关因素。还比较了血液透析治疗前后的血清镁浓度。
收集并分析了148例血液透析患者的数据。血液透析前血清总镁浓度的平均值为1.11±0.14 mmol/L。高镁血症的患病率为73.65%，2例患者有低镁血症（1.35%）。数据分析表明，血小板总数、血清磷水平、血清肌酐、血浆白蛋白和血清总胆固醇水平与血清镁浓度显著相关。使用常规血液透析进行治疗后，血清镁浓度显著降低。血液透析后，血清镁浓度平均下降0.14 mmol/L。
在提供常规透析液时，大多数接受血液透析的患者有轻度高镁血症。血清镁浓度与患者的营养状况有关。血液透析治疗可降低血清总镁浓度。
