Helmholtz-Zentrum Dresden - Rossendorf, 01328, Dresden, Germany.
Technische Universität Dresden, 01062, Dresden, Germany.
Sci Rep. 2020 Jun 4;10(1):9118. doi: 10.1038/s41598-020-65775-7.
Intense laser-driven proton pulses, inherently broadband and highly divergent, pose a challenge to established beamline concepts on the path to application-adapted irradiation field formation, particularly for 3D. Here we experimentally show the successful implementation of a highly efficient (50% transmission) and tuneable dual pulsed solenoid setup to generate a homogeneous (laterally and in depth) volumetric dose distribution (cylindrical volume of 5 mm diameter and depth) at a single pulse dose of 0.7 Gy via multi-energy slice selection from the broad input spectrum. The experiments were conducted at the Petawatt beam of the Dresden Laser Acceleration Source Draco and were aided by a predictive simulation model verified by proton transport studies. With the characterised beamline we investigated manipulation and matching of lateral and depth dose profiles to various desired applications and targets. Using an adapted dose profile, we performed a first proof-of-technical-concept laser-driven proton irradiation of volumetric in-vitro tumour tissue (SAS spheroids) to demonstrate concurrent operation of laser accelerator, beam shaping, dosimetry and irradiation procedure of volumetric biological samples.
强激光驱动的质子脉冲具有固有宽带和高度发散的特点，这对适用于辐射场形成的现有束线概念提出了挑战，特别是对于 3D 情况。在这里，我们通过从宽输入光谱中选择多能切片，实验证明了一种高效（50%传输率）且可调谐的双脉冲螺线管装置的成功实现，该装置可在单个脉冲剂量为 0.7Gy 的情况下生成均匀（横向和深度）的体积剂量分布（直径为 5mm、深度为 5mm 的圆柱体积）。实验是在德累斯顿激光加速源 Draco 的皮瓦束上进行的，并得到了质子输运研究验证的预测模拟模型的辅助。通过对特征化的束线，我们研究了对各种预期应用和目标的横向和深度剂量分布的操纵和匹配。我们使用适应性剂量分布，首次对体积体外肿瘤组织（SAS 球体）进行了激光驱动质子辐照的技术概念验证，以证明激光加速器、束流成形、剂量测量和体积生物样品辐照过程的同步操作。
