用于预防 COVID-19 的疫苗再利用方法：MMR 疫苗能否降低发病率和死亡率？
Vaccine repurposing approach for preventing COVID 19: can MMR vaccines reduce morbidity and mortality?
机构信息
School of Biosciences & Technology, Vellore Institute of Technology , Vellore, India.
School of Sports and Health Sciences, Cardiff Metropolitan University , Cardiff, UK.
出版信息
Hum Vaccin Immunother. 2020 Sep 1;16(9):2217-2218. doi: 10.1080/21645515.2020.1773141. Epub 2020 Jun 5.
The coronavirus disease (COVID-19) is resulting in millions of infected individuals with several hundred thousands dead throughout the world. Amidst all the havoc, one interesting observation in the present COVID-19 pandemic is the negligible symptoms in the young; particularly children below 10 years of age. We assume the extensive pediatric vaccination with MMR vaccines followed globally could have resulted in innate immune responses, e.g., induction of interferons (IFNs) and activated natural killer (NK) cells, thereby offering natural immunity against SARS-CoV-2 in the young population. Possible cross-protective innate immunity offered by MMR vaccination prompted us to suggest repurposing MMR vaccination for immuno-prophylaxis against COVID-19.
冠状病毒病（COVID-19）在全球范围内导致数百万人感染，数十万人死亡。在这场混乱中，目前 COVID-19 大流行中的一个有趣观察结果是年轻人（特别是 10 岁以下的儿童）几乎没有症状。我们假设全球范围内广泛使用麻疹、腮腺炎和风疹（MMR）疫苗进行小儿接种可能导致了先天免疫反应，例如，诱导干扰素（IFNs）和活化的自然杀伤（NK）细胞，从而为年轻人群提供了针对 SARS-CoV-2 的天然免疫力。MMR 疫苗提供的可能具有交叉保护作用的先天免疫促使我们建议重新利用 MMR 疫苗进行 COVID-19 的免疫预防。
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