Zhiming Yuan
National Biosafety Laboratory (Wuhan), Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.
J Biosaf Biosecur. 2019 Sep;1(2):123-127. doi: 10.1016/j.jobb.2019.09.005. Epub 2019 Oct 24.
High-level biosafety laboratories are safe and secure platforms which integrate reliable containment, well-trained personnel, and specific biosafety manuals and practices to protect researchers from being infected while manipulating microbial pathogens and prevent pathogens from being released into the outside environment. During the past decades, laboratories with different protection levels have been constructed and operated, the legal framework and a laboratory biosafety management system have been established, and these operational laboratories have played an essential role in combatting emerging and re-emerging infectious diseases in China. Here, we have summarized the significant achievements of high-level laboratory planning, construction, and operation in China, as well as the challenges that we face in the future. Additionally, we have briefly discussed the national plan for construction of high-level biosafety laboratories from 2016-2025 and "biosafety-motivated" management system. This review might be informative for further understanding the present situation and future function of high-level biosafety laboratories in China.
高级别生物安全实验室是安全可靠的平台，它整合了可靠的防护设施、训练有素的人员以及特定的生物安全手册和操作规程，以保护研究人员在处理微生物病原体时不被感染，并防止病原体释放到外部环境中。在过去几十年里，我国建设并运行了不同防护级别的实验室，建立了法律框架和实验室生物安全管理体系，这些运行中的实验室在抗击我国新发和再发传染病方面发挥了重要作用。在此，我们总结了我国高级别实验室规划、建设和运行方面取得的重大成就，以及未来面临的挑战。此外，我们还简要讨论了2016 - 2025年高级别生物安全实验室建设的国家规划和“以生物安全为导向”的管理体系。这篇综述可能有助于进一步了解我国高级别生物安全实验室的现状和未来作用。
