超声降解白蛋白纳米平台用于原位控制药物释放。
Ultrasound-degradable serum albumin nanoplatform for in situ controlled drug release.
机构信息
State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China.
出版信息
Chem Commun (Camb). 2020 Jul 11;56(54):7503-7506. doi: 10.1039/d0cc01937b. Epub 2020 Jun 5.
PMID:32501465
Abstract
In this work, bovine serum albumin-based nanoparticles, BSA-ACVA-DOX NPs, were fabricated for ultrasound-driven drug release, and exhibited excellent tissue penetration. Moreover, a pulsatile release of DOX in vivo could be programmed by in vitro (i.e., remotely) switching the ultrasound on and off.
摘要
在这项工作中，制备了基于牛血清白蛋白的纳米颗粒（BSA-ACVA-DOX NPs），用于超声驱动的药物释放，并表现出优异的组织穿透性。此外，通过体外（即远程）切换超声的开启和关闭，可以对 DOX 的脉冲释放进行编程。
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