State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China.
Chem Commun (Camb). 2020 Jul 11;56(54):7503-7506. doi: 10.1039/d0cc01937b. Epub 2020 Jun 5.
In this work, bovine serum albumin-based nanoparticles, BSA-ACVA-DOX NPs, were fabricated for ultrasound-driven drug release, and exhibited excellent tissue penetration. Moreover, a pulsatile release of DOX in vivo could be programmed by in vitro (i.e., remotely) switching the ultrasound on and off.
在这项工作中，制备了基于牛血清白蛋白的纳米颗粒（BSA-ACVA-DOX NPs），用于超声驱动的药物释放，并表现出优异的组织穿透性。此外，通过体外（即远程）切换超声的开启和关闭，可以对 DOX 的脉冲释放进行编程。
