Chen Peng, Hao Mei-Mei, Zhu Jiang, Yang Zeng-Ye
Department of Neurology, The First Hospital of Yulin, Yulin.
Department of Neurology, Yan'an People's Hospital, Yan'an, China.
Medicine (Baltimore). 2020 Jun 5;99(23):e20315. doi: 10.1097/MD.0000000000020315.
Drug-resistant epilepsy (DRE) is a very tricky disorder, which greatly affects quality of life in such patients. Relevant studies suggested that vagus nerve stimulation (VNS) has potential benefits for DRE. However, there are inconsistent conclusions. The purpose of this study is to investigate whether VNS is effective and safety for DRE.
To collect comprehensive randomized controlled trials (RCTs), the following electronic databases will be retrieved: MEDLINE, EMBASE, Cochrane Library, Web of Science, PsycINFO, CINAHL, AMED, and China National Knowledge Infrastructure from the commencement of each electronic database up to the present with no language restrictions. Two authors will independently carry out all procedures of literature selection, information collection, and risk of bias assessment. Any objections will be worked out by a third author through consultation. The risk of bias for each included trial will be identified using Cochrane risk of bias tool, and statistical analysis will be performed utilizing RevMan 5.3 software.
This study will synthesize the data from the present eligible high quality RCTs to assess whether VNS is effective and safety for DRE.
This study will provide systematic evidence of VNS for the treatment of patients with DRE.
INPLASY202040086.
耐药性癫痫（DRE）是一种非常棘手的疾病，严重影响此类患者的生活质量。相关研究表明，迷走神经刺激（VNS）对DRE可能有益。然而，结论并不一致。本研究的目的是调查VNS治疗DRE的有效性和安全性。
为收集全面的随机对照试验（RCT），将检索以下电子数据库：MEDLINE、EMBASE、Cochrane图书馆、科学网、PsycINFO、CINAHL、AMED以及中国知网，检索时间从各电子数据库建立之初至目前，无语言限制。两位作者将独立进行文献筛选、信息收集和偏倚风险评估的所有程序。如有异议，将由第三位作者通过协商解决。使用Cochrane偏倚风险工具确定每个纳入试验的偏倚风险，并使用RevMan 5.3软件进行统计分析。
本研究将综合现有符合条件的高质量RCT数据，以评估VNS治疗DRE的有效性和安全性。
本研究将为VNS治疗DRE患者提供系统证据。
INPLASY202040086。
