Lili Ma, Yuxiang Fan, Zhongcheng Han, Ying Su, Ru Chen, Rong Xu, Jiang Liu
Department of Oncology, People's Hospital of Xinjiang Uygur Autonomous Region.
The Second Department of Oncology, Traditional Chinese Medical Hospital of Xinjiang Uygur Autonomous Region (The Fourth Affiliated Hospital of Xinjiang Medical University), Urumqi, Xinjiang, China.
Medicine (Baltimore). 2020 Jun 5;99(23):e20551. doi: 10.1097/MD.0000000000020551.
This study aimed to further understand the role of relative telomere length (RTL) in susceptibility to gastric carcinoma (GC) and investigate the association between genetic polymorphisms in the telomere length related genes and GC risk.RTL was measured using the real-time quantitative polymerase chain reaction from 1000 patients and 1100 healthy controls. Genotyping was performed using the Agena MassARRAY platform. The statistical analysis was performed using the chi-square/ Welch T tests, Mann-Whitney U test, and logistic regression analysis.The association analysis of telomere length and GC showed that the RTL in the case group was shorter than in the controls, and the shorter RTL was associated with an increased risk of GC. The association analysis between telomere length related genes polymorphisms and genetic susceptibility to GC indicated that: In the allele models and genetic models, TERT (rs10069690, rs2242652 and rs2853676) and TN1F1 (rs7708392 and rs10036748) were significantly associated with an increased risk of GC. In addition, the haplotype 'Grs10069690Crs2242652" of TERT and the haplotype 'Grs7708392Trs10036748" of TNIP1 were associated with an increased risk of GCOur results suggested that shorter RTL was associated with an increased risk of GC; The association analysis have identified that the TERT (rs10069690, rs2242652 and rs2853676) and TN1P1 (rs7708392 and rs10036748) were associated with GC risk.
本研究旨在进一步了解相对端粒长度（RTL）在胃癌（GC）易感性中的作用，并探讨端粒长度相关基因的基因多态性与GC风险之间的关联。采用实时定量聚合酶链反应对1000例患者和1100例健康对照进行RTL检测。使用Agena MassARRAY平台进行基因分型。采用卡方检验/ Welch t检验、Mann-Whitney U检验和逻辑回归分析进行统计分析。端粒长度与GC的关联分析表明，病例组的RTL短于对照组，较短的RTL与GC风险增加相关。端粒长度相关基因多态性与GC遗传易感性的关联分析表明：在等位基因模型和遗传模型中，TERT（rs10069690、rs2242652和rs2853676）和TN1F1（rs7708392和rs10036748）与GC风险增加显著相关。此外，TERT的单倍型“Grs10069690Crs2242652”和TNIP1的单倍型“Grs7708392Trs10036748”与GC风险增加相关。我们的结果表明，较短的RTL与GC风险增加相关；关联分析确定TERT（rs10069690、rs2242652和rs2853676）和TN1P1（rs7708392和rs10036748）与GC风险相关。
