Liu Zhao, Shi Yuting, Na Yuyan, Zhang Qi, Cao Sizhe, Duan Xianglong, Zhang Xiyang, Yang Hua, Jin Tianbo, Li Yiming
Department of General Surgery, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710004, China.
Department of Surgery, Xi'an Chest Hospital, Xi'an TB&Thoracic Tumor Hospital, Xi'an 710100, China.
Oncotarget. 2016 Jun 28;7(26):40500-40507. doi: 10.18632/oncotarget.9637.
The distribution and levels of TNIP1 in malignant and normal gastric mucosa are different, but it is not known whether TNIP1 polymorphisms are related to gastric carcinogenesis. To assess the association between four TNIP1 SNPs (rs3792792, rs4958881, rs7708392, rs10036748) and carcinogenesis, we used Sequenom Mass-ARRAY technology to determine the genotypes of 302 gastric carcinoma patients and 300 healthy controls in a Northwest Chinese Han population. These data were then compared using the Chi-square test/Fisher's exact test, genetic model analysis, and haplotype analysis. Odds ratios (OR) and 95% confidence intervals (CI) were used to evaluate the correlation. We observed that patients with the "G" allele of rs7708392 and the "C" allele of rs10036748 showed an increased risk of gastric carcinoma (OR= 1.335, 95%CI: 1.021-1.745, P= 0.035; OR= 1.358, 95%CI: 1.039-1.774, P= 0.025, respectively). Conversely, the haplotype "CT" of TNIP1 (rs7708392-rs10036748) may act as a genetic protective factor for gastric carcinoma (adjusted OR= 0.731, 95%CI: 0.552-0.970, P= 0.030). Our results are the first to suggest that genetic variation in TNIP1 gene is associated with gastric carcinoma, though, this finding must be confirmed in other populations with larger sample size.
TNIP1在恶性和正常胃黏膜中的分布及水平存在差异，但尚不清楚TNIP1基因多态性是否与胃癌发生相关。为评估TNIP1的4个单核苷酸多态性（SNP，rs3792792、rs4958881、rs7708392、rs10036748）与胃癌发生的关联，我们采用Sequenom Mass-ARRAY技术对中国西北汉族人群中的302例胃癌患者和300例健康对照者进行基因分型。然后使用卡方检验/费舍尔精确检验、遗传模型分析和单倍型分析对这些数据进行比较。采用优势比（OR）和95%置信区间（CI）评估相关性。我们观察到，携带rs7708392的“G”等位基因和rs10036748的“C”等位基因的患者患胃癌的风险增加（OR分别为1.335，95%CI：1.021 - 1.745，P = 0.035；OR为1.358，95%CI：1.039 - 1.774，P = 0.025）。相反，TNIP1（rs7708392 - rs10036748）的单倍型“CT”可能是胃癌的遗传保护因素（校正OR = 0.731，95%CI：0.552 - 0.970，P = 0.030）。我们的结果首次表明TNIP1基因的遗传变异与胃癌相关，不过，这一发现必须在其他更大样本量的人群中得到证实。
