Shi Yuting, Zhang Lihua, Bao Yang, Wu Pengfei, Zhang Xiaoli
Cadre Health Care Center, Inner Mongolia Autonomous Region People's Hospital, Saihan District, Hohhot.
Department of Pediatric Orthopedics.
Medicine (Baltimore). 2021 Mar 26;100(12):e24843. doi: 10.1097/MD.0000000000024843.
Study has demonstrated that TNIP1 polymorphisms are associated with an increased risk of HBV-induced hepatocellular carcinoma (HCC). The purpose of this study was to investigate the correlation between polymorphisms in TNIP1 and HCC risk in a Northwest Chinese Han population.A case-control study was conducted including 473 Hepatocellular carcinoma patients and 564 healthy controls. Three SNPs (rs3792792, rs7708392, and rs10036748) were genotyped with Sequenom MassARRAY technology and their associations with HCC risk were analyzed. These data were evaluated using the Chi-square test/Fisher's exact test, genetic model analysis, and haplotype analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association.Patients with the "G" allele of TNIP1 rs7708392 showed a significantly increased risk of HCC (OR = 1.24, 95%CI: 1.01-1.52, P = .042). Significant association was also shown between TNIP1 rs7708392 and HCC susceptibility in Additive model (OR = 1.25; 95% CI = 1.01-1.54; P = .040). Besides, we also found that the "GC" haplotype of rs7708392 and rs10036748 was significantly associated with higher occurrence of HCC (OR = 1.25, 95% CI: 1.01-1.54, P = .039).These results demonstrate that TNIP1 polymorphisms are associated with increased HCC risk in a Northwest Chinese Han population for the first time, which warrants further investigation in the future.
研究表明，TNIP1基因多态性与乙肝病毒诱导的肝细胞癌（HCC）风险增加相关。本研究旨在调查中国西北汉族人群中TNIP1基因多态性与HCC风险之间的相关性。进行了一项病例对照研究，包括473例肝细胞癌患者和564例健康对照。采用Sequenom MassARRAY技术对3个单核苷酸多态性（SNP，rs3792792、rs7708392和rs10036748）进行基因分型，并分析它们与HCC风险的关联。使用卡方检验/费舍尔精确检验、遗传模型分析和单倍型分析对这些数据进行评估。采用95%置信区间（CI）的比值比（OR）来评估关联性。携带TNIP1 rs7708392 “G” 等位基因的患者患HCC的风险显著增加（OR = 1.24，95%CI：1.01 - 1.52，P = 0.04）。在加性模型中，TNIP1 rs7708392与HCC易感性之间也显示出显著关联（OR = 1.25；95% CI = 1.01 - 1.54；P = 0.04）。此外，我们还发现rs7708392和rs10036748的 “GC” 单倍型与HCC的较高发生率显著相关（OR = 1.25，95% CI：1.01 - 1.54，P = 0.039）。这些结果首次证明TNIP1基因多态性与中国西北汉族人群中HCC风险增加相关，这值得未来进一步研究。
