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老年髋部骨折患者院内死亡预测模型的开发与内部验证

Development and Internal Validation of a Prediction Model for In-Hospital Mortality in Geriatric Patients With a Hip Fracture.

作者信息

Schuijt Henk Jan, Smeeing Diederik P J, Würdemann Franka S, Hegeman J Han, Geraghty Olivia C, Houwert R Marijn, Weaver Michael J, van der Velde Detlef

机构信息

Department of Surgery, Sint Antonius Hospital, Utrecht, the Netherlands.

Department of Surgery, University Medical Center Utrecht, Utrecht, the Netherlands.

出版信息

J Orthop Trauma. 2020 Dec 1;34(12):656-661. doi: 10.1097/BOT.0000000000001851.

Abstract

OBJECTIVE

To develop and validate a prediction model for in-hospital mortality in patients with hip fracture 85 years of age or older undergoing surgery.

DESIGN

A multicenter prospective cohort study.

SETTING

Six Dutch trauma centers, level 2 and 3.

PARTICIPANTS

Patients with hip fracture 85 years of age or older undergoing surgery.

INTERVENTION

Hip fracture surgery.

MAIN OUTCOME MEASUREMENTS

In-hospital mortality.

RESULTS

The development cohort consisted of 1014 patients. In-hospital mortality was 4%. Age, male sex, American Society of Anesthesiologists classification, and hemoglobin levels at presentation were independent predictors of in-hospital mortality. The bootstrap adjusted performance showed good discrimination with a c-statistic of 0.77.

CONCLUSION

Age, male sex, higher American Society of Anesthesiologists classification, and lower hemoglobin levels at presentation are robust independent predictors of in-hospital mortality in patients with geriatric hip fracture and were incorporated in a simple prediction model with good accuracy and no lack of fit.

LEVEL OF EVIDENCE

Prognostic Level II. See Instructions for Authors for a complete description of levels of evidence.

摘要

目的

开发并验证一种针对85岁及以上接受手术的髋部骨折患者院内死亡率的预测模型。

设计

多中心前瞻性队列研究。

地点

荷兰6家二级和三级创伤中心。

参与者

85岁及以上接受手术的髋部骨折患者。

干预措施

髋部骨折手术。

主要观察指标

院内死亡率。

结果

开发队列包括1014例患者。院内死亡率为4%。年龄、男性、美国麻醉医师协会分级以及入院时的血红蛋白水平是院内死亡率的独立预测因素。自展法调整后的性能显示出良好的区分度,c统计量为0.77。

结论

年龄、男性、较高的美国麻醉医师协会分级以及入院时较低的血红蛋白水平是老年髋部骨折患者院内死亡率的有力独立预测因素,并被纳入一个简单的预测模型,该模型具有良好的准确性且不存在拟合不足的问题。

证据级别

预后II级。有关证据级别的完整描述,请参阅作者指南。

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