Center for Primary Health Care Research, Lund University, Malmö, Sweden.
J Nerv Ment Dis. 2020 Sep;208(9):637-645. doi: 10.1097/NMD.0000000000001190.
To determine whether alcohol use disorder (AUD) is transmitted within families as predicted by contagion, we examined parent-offspring, siblings, and cousin pairs ascertained from Swedish registries with a primary case with AUD. Our outcome variable was AUD registration in at-risk secondary cases. In offspring, risks for AUD registration in the 3 years after a parental index registration residing in the same household, neighborhood, or municipality increased by 1.6%, -0.5%, and 0.3%, respectively. For siblings of sibling index cases, parallel results were 3.2%, 1.2%, and 0.3%. For cousins of cousin index cases, no excess risk was seen for those residing in the same neighborhood or municipality. In siblings, AUD transmission was stronger in same versus opposite sex pairs and from older to younger versus younger to older siblings. These results support the hypothesis that AUD is transmitted among close family relationships and over limited geographical distances by a temporally dynamic contagion model.
为了确定酒精使用障碍（AUD）是否像传染病那样在家庭中传播，我们研究了来自瑞典登记处的父母-子女、兄弟姐妹和表亲对，这些家庭中有一个主要病例患有 AUD。我们的结果变量是高危二级病例的 AUD 登记。在子女中，与父母指数登记居住在同一家庭、同一街区或同一市镇的情况下，子女在父母指数登记后 3 年内 AUD 登记的风险分别增加了 1.6%、-0.5%和 0.3%。对于兄弟姐妹指数病例的兄弟姐妹，平行结果分别为 3.2%、1.2%和 0.3%。对于表亲指数病例的表亲，居住在同一街区或同一市镇的表亲没有出现超额风险。在兄弟姐妹中，同性别对之间的 AUD 传播要强于异性别对，而且是从年长的兄弟姐妹到年幼的兄弟姐妹的传播要强于相反情况。这些结果支持 AUD 是通过暂时动态传染模型在近亲关系和有限的地理距离内传播的假设。
