Andersson S, Kronström A, Teien D
Department of Clinical Physiology, University of Umeå, Sweden.
Acta Physiol Scand. 1988 Dec;134(4):457-61. doi: 10.1111/j.1748-1716.1998.tb08518.x.
The hydrodynamic properties of the rat bladder in the collection phase were examined by slow continuous and very fast stepwise cystometry in nine rats. In vivo, the fast volume steps induced a reproducible detrusor contraction (type A) which remained after spinal anaesthesia and anticholinergic treatment, but ceased post-mortally within 1 h. No significant effect of anticholinergic treatment was found on bladder stiffness. The stiffness and relaxation time of the bladder wall increased markedly at large distension. At small and moderate distension, however, the compliances evaluated from continuous and stepwise cystometry were nearly the same, and a linear elastic model of the bladder was applicable. We consider that the rat bladder will be a useful experimental model in further research on viscoelasticity and instability of the bladder wall.
通过对9只大鼠进行缓慢连续和非常快速的分步膀胱测压，研究了大鼠膀胱在收集期的流体动力学特性。在体内，快速的容量步移会诱发可重复的逼尿肌收缩（A型），这种收缩在脊髓麻醉和抗胆碱能治疗后仍会持续，但在死后1小时内停止。未发现抗胆碱能治疗对膀胱硬度有显著影响。膀胱壁的硬度和松弛时间在大扩张时显著增加。然而，在小扩张和中等扩张时，连续和分步膀胱测压评估的顺应性几乎相同，膀胱的线性弹性模型适用。我们认为，大鼠膀胱将成为进一步研究膀胱壁粘弹性和不稳定性的有用实验模型。
