Andersson S, Kronström A, Hentschel J
Department of Clinical Physiology, University of Umeå, Sweden.
Acta Physiol Scand. 1988 Dec;134(4):463-6. doi: 10.1111/j.1748-1716.1998.tb08519.x.
The hydrodynamic properties of the urinary bladder in rat were examined by means of very small periodic changes in volume at different frequencies. The elastance increased with increasing frequency of volume changes, indicating the presence of viscoelastic elements. When the bladder was only moderately distended the influence of viscosity was minor. We consider that the rat bladder examined by this technique is an ideal experimental model for assessment of in vivo effects of pharmacological agents on bladder wall tonus. For example, cholinergic treatment showed a 100% increase in elastance and atropine inhibited this effect completely within 3 min.
通过在不同频率下对大鼠膀胱进行非常小的周期性容积变化来检测其流体动力学特性。弹性随着容积变化频率的增加而增加，表明存在粘弹性成分。当膀胱仅适度扩张时，粘度的影响较小。我们认为，用这种技术检测的大鼠膀胱是评估药物对膀胱壁张力的体内效应的理想实验模型。例如，胆碱能治疗使弹性增加了100%，阿托品在3分钟内完全抑制了这种效应。
