Department of Molecular Biology, Faculty of Sciences, University of Geneva, Geneva, Switzerland.
Mol Cell. 2020 Jun 4;78(5):805-807. doi: 10.1016/j.molcel.2020.05.010.
The amplitude of circadian rhythms dampens with age, but Levine et al. (2020) now show that nicotinamide adenine dinucleotide (NAD+) can restore robust circadian gene expression and behavior in aged mice through SIRT1-dependent deacetylation of the core clock protein PER2.
昼夜节律的幅度随年龄增长而减弱，但 Levine 等人（2020 年）现在表明，烟酰胺腺嘌呤二核苷酸（NAD+）可以通过核心时钟蛋白 PER2 的 SIRT1 依赖性去乙酰化作用恢复老年小鼠中强大的昼夜节律基因表达和行为。
