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通过烟酰胺磷酸核糖转移酶（NAMPT）介导的烟酰胺腺嘌呤二核苷酸（NAD+）生物合成的昼夜节律时钟反馈循环。

Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis.

作者信息

Ramsey Kathryn Moynihan, Yoshino Jun, Brace Cynthia S, Abrassart Dana, Kobayashi Yumiko, Marcheva Biliana, Hong Hee-Kyung, Chong Jason L, Buhr Ethan D, Lee Choogon, Takahashi Joseph S, Imai Shin-Ichiro, Bass Joseph

机构信息

Department of Medicine, Northwestern University Feinberg School of Medicine, 2200 Campus Drive, Evanston, IL 60208-3500, USA.

出版信息

Science. 2009 May 1;324(5927):651-4. doi: 10.1126/science.1171641. Epub 2009 Mar 19.

DOI:10.1126/science.1171641
PMID:19299583
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2738420/
Abstract

The circadian clock is encoded by a transcription-translation feedback loop that synchronizes behavior and metabolism with the light-dark cycle. Here we report that both the rate-limiting enzyme in mammalian nicotinamide adenine dinucleotide (NAD+) biosynthesis, nicotinamide phosphoribosyltransferase (NAMPT), and levels of NAD+ display circadian oscillations that are regulated by the core clock machinery in mice. Inhibition of NAMPT promotes oscillation of the clock gene Per2 by releasing CLOCK:BMAL1 from suppression by SIRT1. In turn, the circadian transcription factor CLOCK binds to and up-regulates Nampt, thus completing a feedback loop involving NAMPT/NAD+ and SIRT1/CLOCK:BMAL1.

摘要

昼夜节律钟由一个转录-翻译反馈环编码，该反馈环使行为和代谢与明暗周期同步。我们在此报告，哺乳动物烟酰胺腺嘌呤二核苷酸（NAD+）生物合成中的限速酶烟酰胺磷酸核糖基转移酶（NAMPT）以及NAD+水平均呈现昼夜振荡，且受小鼠核心生物钟机制调控。抑制NAMPT可通过解除SIRT1对CLOCK:BMAL1的抑制来促进生物钟基因Per2的振荡。反过来，昼夜节律转录因子CLOCK结合并上调Nampt，从而完成一个涉及NAMPT/NAD+和SIRT1/CLOCK:BMAL1的反馈环。

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本文引用的文献

1
Nicotinamide phosphoribosyltransferase (Nampt): a link between NAD biology, metabolism, and diseases.烟酰胺磷酸核糖转移酶（Nampt）：NAD生物学、代谢与疾病之间的联系。
Curr Pharm Des. 2009;15(1):20-8. doi: 10.2174/138161209787185814.
2
The genetics of mammalian circadian order and disorder: implications for physiology and disease.哺乳动物昼夜节律的有序与紊乱遗传学：对生理学和疾病的影响。
Nat Rev Genet. 2008 Oct;9(10):764-75. doi: 10.1038/nrg2430.
3
High-fat diet delays and fasting advances the circadian expression of adiponectin signaling components in mouse liver.高脂饮食会延迟，而禁食会提前小鼠肝脏中脂联素信号成分的昼夜节律表达。
Endocrinology. 2009 Jan;150(1):161-8. doi: 10.1210/en.2008-0944. Epub 2008 Sep 18.
4
The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control.烟酰胺腺嘌呤二核苷酸（NAD⁺）依赖性脱乙酰酶SIRT1调节由生物钟蛋白（CLOCK）介导的染色质重塑和昼夜节律调控。
Cell. 2008 Jul 25;134(2):329-40. doi: 10.1016/j.cell.2008.07.002.
5
SIRT1 regulates circadian clock gene expression through PER2 deacetylation.沉默调节蛋白1通过对周期蛋白2进行去乙酰化作用来调节生物钟基因的表达。
Cell. 2008 Jul 25;134(2):317-28. doi: 10.1016/j.cell.2008.06.050.
6
Tissue-specific regulation of SIRT1 by calorie restriction.卡路里限制对SIRT1的组织特异性调节。
Genes Dev. 2008 Jul 1;22(13):1753-7. doi: 10.1101/gad.1650608. Epub 2008 Jun 11.
7
Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt.葡萄糖限制通过AMPK介导的Nampt调节激活SIRT1，从而抑制骨骼肌成肌细胞分化。
Dev Cell. 2008 May;14(5):661-73. doi: 10.1016/j.devcel.2008.02.004.
8
High-fat diet disrupts behavioral and molecular circadian rhythms in mice.高脂饮食会扰乱小鼠的行为和分子昼夜节律。
Cell Metab. 2007 Nov;6(5):414-21. doi: 10.1016/j.cmet.2007.09.006.
9
Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme.烟酰胺磷酸核糖转移酶/前B细胞克隆增强因子/内脂素作为一种全身性烟酰胺腺嘌呤二核苷酸生物合成酶，可调节β细胞中的胰岛素分泌。
Cell Metab. 2007 Nov;6(5):363-75. doi: 10.1016/j.cmet.2007.09.003.
10
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival.营养敏感型线粒体NAD+水平决定细胞存活。
Cell. 2007 Sep 21;130(6):1095-107. doi: 10.1016/j.cell.2007.07.035.