Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY 12144, USA.
Department of Biochemistry, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, Egypt.
Molecules. 2020 Jun 3;25(11):2597. doi: 10.3390/molecules25112597.
One of the major causes of women's death in the world is breast cancer. Consequently, numerous regimens for the control of this severe disease have been created. The chemotherapeutic agent doxorubicin (DOX) is frequently used to treat breast cancer, but DOX can also cause cardiotoxic effects that lead to heart failure. Therefore, many research studies have been done to find a natural product that effectively potentiates or does not interfere with DOX's anticancer effect and protects against its cardiotoxicity. We studied the impact of combined nanoformulated Ajwa (Phoenix dactylifera) selected bioactive compounds (BAC) rutin (R) and quercetin (Q) in nude mice breast cancer xenografts on DOX-mediated anticancer efficacy. We also studied if this Ajwa BAC could safeguard against DOX-mediated cardiomyopathies by evaluating plasma cardiac troponin-I (cTn-I) levels and cardiac histopathology. Nanoformulated Ajwa BAC effectively alleviated weight loss induced by DOX in mice and significantly decreased the elevated cTn-I. Furthermore, 5 mg RQ-NPs/kg of nude mice that subcutaneously daily injected for 11 days, attenuated the histopathological alterations induced in cardiac muscles due to DOX without any interference with the anticancer effects of DOX against breast cancer.
全世界导致女性死亡的主要原因之一是乳腺癌。因此，已经开发出许多控制这种严重疾病的方案。化疗药物阿霉素（DOX）常用于治疗乳腺癌，但 DOX 也会引起心脏毒性作用，导致心力衰竭。因此，许多研究都在寻找一种天然产物，既能有效增强 DOX 的抗癌作用而不干扰其作用，又能预防其心脏毒性。我们研究了纳米配方化的阿吉瓦（海枣）选择的生物活性化合物（BAC）芦丁（R）和槲皮素（Q）在裸鼠乳腺癌异种移植中的联合作用对 DOX 介导的抗癌疗效的影响。我们还研究了这种阿吉瓦 BAC 是否可以通过评估血浆心肌肌钙蛋白 I（cTn-I）水平和心脏组织病理学来预防 DOX 介导的心肌病。纳米配方化的阿吉瓦 BAC 能有效缓解 DOX 诱导的小鼠体重减轻，并显著降低升高的 cTn-I。此外，每天皮下注射 5 毫克 RQ-NPs/kg 的裸鼠 11 天，可减轻 DOX 引起的心肌组织的组织病理学改变，而不干扰 DOX 对乳腺癌的抗癌作用。
