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白藜芦醇及其纳米制剂抑制异种移植和原位结肠癌模型的生长和血管生成。

Resveratrol and Its Nanoformulation Attenuate Growth and the Angiogenesis of Xenograft and Orthotopic Colon Cancer Models.

机构信息

Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY 12144, USA.

Department of Biochemistry, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, Egypt.

出版信息

Molecules. 2020 Mar 20;25(6):1412. doi: 10.3390/molecules25061412.

DOI:10.3390/molecules25061412
PMID:32244860
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7144556/
Abstract

Cancer is a multifactorial disorder that induces mortality worldwide, and the colorectal type is the third most common cancer globally. Resveratrol (RSV) is a natural compound with an effective anticancer effect, especially against colorectal cancer, and therefore numerous studies recommended its use in colorectal cancer prevention and treatment. The current study investigated the effect of either RSV or its nanoformulation (NP-RSV) on the growth and vascularity of xenograft and orthotopic mice models in colon cancer (COLO205-luc). Both RSV and NP-RSV induced significant reductions in tumor growth and the hemoglobin percentages of the tumor mass, but NP-RSV showed greater bioavailability and efficacy than RSV. Generally, we recommend using NP-RSV as a therapeutic to control colon cancer.

摘要

癌症是一种多因素疾病，在全球范围内导致死亡率升高，而结直肠癌是全球第三常见的癌症。白藜芦醇（RSV）是一种具有有效抗癌作用的天然化合物，特别是对结直肠癌，因此许多研究建议将其用于结直肠癌的预防和治疗。本研究探讨了 RSV 或其纳米制剂（NP-RSV）对异种移植和原位小鼠模型中结肠癌（COLO205-luc）生长和血管生成的影响。RSV 和 NP-RSV 均显著抑制肿瘤生长和肿瘤质量的血红蛋白百分比，但 NP-RSV 的生物利用度和疗效优于 RSV。一般来说，我们建议使用 NP-RSV 作为治疗药物来控制结肠癌。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cccf/7144556/61491133a759/molecules-25-01412-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cccf/7144556/83d5c9d3a79d/molecules-25-01412-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cccf/7144556/dfb35dcd5699/molecules-25-01412-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cccf/7144556/1a13ad60d4cf/molecules-25-01412-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cccf/7144556/64f6b20fe443/molecules-25-01412-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cccf/7144556/9b5eac72df60/molecules-25-01412-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cccf/7144556/fc9a654b4913/molecules-25-01412-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cccf/7144556/110de842a5a3/molecules-25-01412-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cccf/7144556/61491133a759/molecules-25-01412-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cccf/7144556/83d5c9d3a79d/molecules-25-01412-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cccf/7144556/dfb35dcd5699/molecules-25-01412-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cccf/7144556/1a13ad60d4cf/molecules-25-01412-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cccf/7144556/64f6b20fe443/molecules-25-01412-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cccf/7144556/9b5eac72df60/molecules-25-01412-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cccf/7144556/fc9a654b4913/molecules-25-01412-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cccf/7144556/110de842a5a3/molecules-25-01412-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cccf/7144556/61491133a759/molecules-25-01412-g008.jpg

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