白藜芦醇及其纳米制剂抑制异种移植和原位结肠癌模型的生长和血管生成。
Resveratrol and Its Nanoformulation Attenuate Growth and the Angiogenesis of Xenograft and Orthotopic Colon Cancer Models.
机构信息
Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY 12144, USA.
Department of Biochemistry, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, Egypt.
出版信息
Molecules. 2020 Mar 20;25(6):1412. doi: 10.3390/molecules25061412.
Abstract
Cancer is a multifactorial disorder that induces mortality worldwide, and the colorectal type is the third most common cancer globally. Resveratrol (RSV) is a natural compound with an effective anticancer effect, especially against colorectal cancer, and therefore numerous studies recommended its use in colorectal cancer prevention and treatment. The current study investigated the effect of either RSV or its nanoformulation (NP-RSV) on the growth and vascularity of xenograft and orthotopic mice models in colon cancer (COLO205-luc). Both RSV and NP-RSV induced significant reductions in tumor growth and the hemoglobin percentages of the tumor mass, but NP-RSV showed greater bioavailability and efficacy than RSV. Generally, we recommend using NP-RSV as a therapeutic to control colon cancer.
摘要
癌症是一种多因素疾病，在全球范围内导致死亡率升高，而结直肠癌是全球第三常见的癌症。白藜芦醇（RSV）是一种具有有效抗癌作用的天然化合物，特别是对结直肠癌，因此许多研究建议将其用于结直肠癌的预防和治疗。本研究探讨了 RSV 或其纳米制剂（NP-RSV）对异种移植和原位小鼠模型中结肠癌（COLO205-luc）生长和血管生成的影响。RSV 和 NP-RSV 均显著抑制肿瘤生长和肿瘤质量的血红蛋白百分比，但 NP-RSV 的生物利用度和疗效优于 RSV。一般来说，我们建议使用 NP-RSV 作为治疗药物来控制结肠癌。
相似文献
1
Resveratrol and Its Nanoformulation Attenuate Growth and the Angiogenesis of Xenograft and Orthotopic Colon Cancer Models.
Molecules. 2020 Mar 20;25(6):1412. doi: 10.3390/molecules25061412.
2
A catechin nanoformulation inhibits WM266 melanoma cell proliferation, migration and associated neo-angiogenesis.
Eur J Pharm Biopharm. 2017 May;114:1-10. doi: 10.1016/j.ejpb.2016.12.024. Epub 2017 Jan 11.
3
The Potential Use of Resveratrol for Cancer Prevention.
Molecules. 2019 Dec 9;24(24):4506. doi: 10.3390/molecules24244506.
4
Resveratrol and its nanocrystals: A promising approach for cancer therapy?
Toxicol Appl Pharmacol. 2022 Jan 15;435:115851. doi: 10.1016/j.taap.2021.115851. Epub 2021 Dec 29.
5
The role of reactive oxygen species and subsequent DNA-damage response in the emergence of resistance towards resveratrol in colon cancer models.
Cell Death Dis. 2014 Nov 20;5(11):e1533. doi: 10.1038/cddis.2014.486.
6
Physiological uptake and retention of radiolabeled resveratrol loaded gold nanoparticles (Tc-Res-AuNP) in colon cancer tissue.
Nanomedicine. 2018 Apr;14(3):1059-1071. doi: 10.1016/j.nano.2018.01.008. Epub 2018 Jan 31.
7
Resveratrol metabolites inhibit human metastatic colon cancer cells progression and synergize with chemotherapeutic drugs to induce cell death.
Mol Nutr Food Res. 2013 Jul;57(7):1170-81. doi: 10.1002/mnfr.201200766. Epub 2013 Mar 14.
8
Grape compounds suppress colon cancer stem cells in vitro and in a rodent model of colon carcinogenesis.
BMC Complement Altern Med. 2016 Aug 9;16:278. doi: 10.1186/s12906-016-1254-2.
9
Resveratrol as a Tumor-Suppressive Nutraceutical Modulating Tumor Microenvironment and Malignant Behaviors of Cancer.
Int J Mol Sci. 2019 Feb 20;20(4):925. doi: 10.3390/ijms20040925.
10
Antitumor activity of melinjo (Gnetum gnemon L.) seed extract in human and murine tumor models in vitro and in a colon-26 tumor-bearing mouse model in vivo.
Cancer Med. 2015 Nov;4(11):1767-80. doi: 10.1002/cam4.520. Epub 2015 Sep 26.
引用本文的文献
1
Natural product-based nanotechnological formulations for colorectal cancer treatment.
Naunyn Schmiedebergs Arch Pharmacol. 2025 Apr 25. doi: 10.1007/s00210-025-04175-y.
2
Resveratrol's bibliometric and visual analysis from 2014 to 2023.
Front Plant Sci. 2024 Oct 8;15:1423323. doi: 10.3389/fpls.2024.1423323. eCollection 2024.
3
Therapeutic Applications of Nanoformulated Resveratrol and Quercetin Phytochemicals in Colorectal Cancer-An Updated Review.
Pharmaceutics. 2024 Jun 4;16(6):761. doi: 10.3390/pharmaceutics16060761.
4
Resveratrol in the Treatment of Gynecological Cancer: Mechanisms and Therapeutic Potential.
Curr Med Chem. 2024 May 3. doi: 10.2174/0109298673290941240430171146.
5
Enhancing the Bioavailability of Resveratrol: Combine It, Derivatize It, or Encapsulate It?
Pharmaceutics. 2024 Apr 22;16(4):569. doi: 10.3390/pharmaceutics16040569.
6
Resveratrol Promotes Self-digestion to Put Cancer to Sleep.
J Cancer Prev. 2024 Mar 30;29(1):1-5. doi: 10.15430/JCP.24.001. Epub 2024 Mar 29.
7
Recent Developments in Nanoparticle Formulations for Resveratrol Encapsulation as an Anticancer Agent.
Pharmaceuticals (Basel). 2024 Jan 18;17(1):126. doi: 10.3390/ph17010126.
8
Resveratrol-Laden Nano-Systems in the Cancer Environment: Views and Reviews.
Cancers (Basel). 2023 Sep 10;15(18):4499. doi: 10.3390/cancers15184499.
9
Recent Progress in Nanotechnology Improving the Therapeutic Potential of Polyphenols for Cancer.
Nutrients. 2023 Jul 13;15(14):3136. doi: 10.3390/nu15143136.
10
An Updated Review on the Role of Nanoformulated Phytochemicals in Colorectal Cancer.
Medicina (Kaunas). 2023 Mar 30;59(4):685. doi: 10.3390/medicina59040685.
本文引用的文献
1
Synergy of Ginkgetin and Resveratrol in Suppressing VEGF-Induced Angiogenesis: A Therapy in Treating Colorectal Cancer.
Cancers (Basel). 2019 Nov 20;11(12):1828. doi: 10.3390/cancers11121828.
2
Colorectal cancer.
Lancet. 2019 Oct 19;394(10207):1467-1480. doi: 10.1016/S0140-6736(19)32319-0.
3
Resveratrol inhibits the invasion and metastasis of colon cancer through reversal of epithelial‑ mesenchymal transition via the AKT/GSK‑3β/Snail signaling pathway.
Mol Med Rep. 2019 Sep;20(3):2783-2795. doi: 10.3892/mmr.2019.10528. Epub 2019 Jul 25.
4
Resveratrol is a promising agent for colorectal cancer prevention and treatment: focus on molecular mechanisms.
Cancer Cell Int. 2019 Jul 15;19:180. doi: 10.1186/s12935-019-0906-y. eCollection 2019.
5
Mitochondria-Targeted and Resveratrol-Loaded Dual-Function Titanium Disulfide Nanosheets for Photothermal-Triggered Tumor Chemotherapy.
Nanoscale Res Lett. 2019 Jun 21;14(1):211. doi: 10.1186/s11671-019-3044-5.
6
Resveratrol suppresses colon cancer growth by targeting the AKT/STAT3 signaling pathway.
Int J Mol Med. 2019 Jan;43(1):630-640. doi: 10.3892/ijmm.2018.3969. Epub 2018 Nov 1.
7
Increased Oral Bioavailability of Resveratrol by Its Encapsulation in Casein Nanoparticles.
Int J Mol Sci. 2018 Sep 18;19(9):2816. doi: 10.3390/ijms19092816.
8
Resveratrol: A Double-Edged Sword in Health Benefits.
Biomedicines. 2018 Sep 9;6(3):91. doi: 10.3390/biomedicines6030091.
9
Resveratrol-loaded PLGA nanoparticles mediated programmed cell death in prostate cancer cells.
Saudi Pharm J. 2018 Sep;26(6):876-885. doi: 10.1016/j.jsps.2018.03.009. Epub 2018 Mar 15.
10
Anticancer Effects of Resveratrol-Loaded Solid Lipid Nanoparticles on Human Breast Cancer Cells.
Molecules. 2017 Oct 25;22(11):1814. doi: 10.3390/molecules22111814.
Zotero 插件