• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

相似文献

1
Acetylcholine and Acetylcholine Receptors: Textbook Knowledge and New Data.乙酰胆碱和乙酰胆碱受体:教科书知识和新数据。
Biomolecules. 2020 Jun 3;10(6):852. doi: 10.3390/biom10060852.
2
Altered isotope charge distribution of acetylcholine neurotransmitter and Myasthenia Gravis.乙酰胆碱神经递质的同位素电荷分布改变与重症肌无力
Med Hypotheses. 2016 Apr;89:84-8. doi: 10.1016/j.mehy.2016.01.019. Epub 2016 Feb 6.
3
Coupling between the nicotinic acetylcholine receptor site and the ionic channel site.烟碱型乙酰胆碱受体位点与离子通道位点之间的偶联。
Ann N Y Acad Sci. 1980;358:239-52. doi: 10.1111/j.1749-6632.1980.tb15398.x.
4
Nuclear magnetic resonance (NMR) analysis of ligand receptor interactions: the cholinergic system--a model.配体-受体相互作用的核磁共振(NMR)分析:胆碱能系统——一个模型
Crit Rev Biochem Mol Biol. 1996;31(4):273-301. doi: 10.3109/10409239609106586.
5
NMR analysis reveals a positively charged hydrophobic domain as a common motif to bound acetylcholine and d-tubocurarine.核磁共振分析显示,一个带正电荷的疏水结构域是结合乙酰胆碱和d-筒箭毒碱的共同基序。
Biochemistry. 1994 Jan 25;33(3):644-50. doi: 10.1021/bi00169a004.
6
Cholinergic modulation of nucleus accumbens medium spiny neurons.伏隔核中等棘状神经元的胆碱能调节
Eur J Neurosci. 2002 Dec;16(12):2279-90. doi: 10.1046/j.1460-9568.2002.02289.x.
7
Molecular and pharmacological characterization of an acetylcholine-gated chloride channel (ACC-2) from the parasitic nematode Haemonchus contortus.寄生性线虫旋毛虫(Haemonchus contortus)乙酰胆碱门控氯离子通道(ACC-2)的分子和药理学特性。
Int J Parasitol Drugs Drug Resist. 2018 Dec;8(3):518-525. doi: 10.1016/j.ijpddr.2018.09.004. Epub 2018 Sep 22.
8
Peripheral administration of CDP-choline and its cholinergic metabolites increases serum insulin: muscarinic and nicotinic acetylcholine receptors are both involved in their actions.外周给予胞磷胆碱及其胆碱能代谢产物可增加血清胰岛素:毒蕈碱型和烟碱型乙酰胆碱受体均参与其作用。
Neurosci Lett. 2008 Jan 24;431(1):71-6. doi: 10.1016/j.neulet.2007.11.024. Epub 2007 Dec 4.
9
Nicotinic cholinergic receptors labeled by [3H]acetylcholine in rat brain.大鼠脑中由[3H]乙酰胆碱标记的烟碱型胆碱能受体。
Mol Pharmacol. 1982 Jul;22(1):56-62.
10
Detection of nicotinic cholinergic transmission in Malapterurus electricus electroplax.电鲇电器官中烟碱型胆碱能传递的检测。
Life Sci. 1981 Sep 7;29(10):1033-7. doi: 10.1016/0024-3205(81)90463-x.

引用本文的文献

1
A New Era of Muscarinic Acetylcholine Receptor Modulators in Neurological Diseases, Cancer and Drug Abuse.毒蕈碱型乙酰胆碱受体调节剂在神经疾病、癌症和药物滥用领域的新时代。
Pharmaceuticals (Basel). 2025 Mar 5;18(3):369. doi: 10.3390/ph18030369.
2
Metabolomic analysis of rat arterial serum under hypobaric hypoxia: Adaptive regulation of physiological systems by metabolic reprogramming.低压缺氧条件下大鼠动脉血清的代谢组学分析:通过代谢重编程对生理系统的适应性调节
Biochem Biophys Rep. 2025 Feb 18;41:101943. doi: 10.1016/j.bbrep.2025.101943. eCollection 2025 Mar.
3
Effect of Dietary Choline Consumption on the Development of Urinary Urgency Incontinence in a Longitudinal Cohort of Women.膳食胆碱摄入对女性纵向队列尿失禁发展的影响。
Int Urogynecol J. 2024 Mar;35(3):667-676. doi: 10.1007/s00192-024-05740-4. Epub 2024 Feb 9.
4
Gut liver brain axis in diseases: the implications for therapeutic interventions.肠道-肝脏-脑轴在疾病中的作用:治疗干预的意义。
Signal Transduct Target Ther. 2023 Dec 6;8(1):443. doi: 10.1038/s41392-023-01673-4.
5
Royal jelly: a predictive, preventive and personalised strategy for novel treatment options in non-communicable diseases.蜂王浆:一种针对非传染性疾病新治疗方案的预测性、预防性和个性化策略。
EPMA J. 2023 Jul 18;14(3):381-404. doi: 10.1007/s13167-023-00330-8. eCollection 2023 Sep.
6
Potential of Heterogeneous Compounds as Antidepressants: A Narrative Review.异质化合物作为抗抑郁药的潜力:叙事性综述。
Int J Mol Sci. 2022 Nov 9;23(22):13776. doi: 10.3390/ijms232213776.
7
Predictive Value of Preoperative Profiling of Serum Metabolites for Emergence Agitation After General Anesthesia in Adult Patients.成年患者全身麻醉后血清代谢物术前分析对苏醒期躁动的预测价值
Front Mol Biosci. 2021 Oct 21;8:739227. doi: 10.3389/fmolb.2021.739227. eCollection 2021.

本文引用的文献

1
Structure of the Native Muscle-type Nicotinic Receptor and Inhibition by Snake Venom Toxins.天然肌肉型烟碱型乙酰胆碱受体的结构和蛇毒毒素的抑制作用。
Neuron. 2020 Jun 17;106(6):952-962.e5. doi: 10.1016/j.neuron.2020.03.012. Epub 2020 Apr 9.
2
Discovery of the First Neurotransmitter Receptor: The Acetylcholine Nicotinic Receptor.发现第一种神经递质受体:乙酰胆碱烟碱受体。
Biomolecules. 2020 Apr 3;10(4):547. doi: 10.3390/biom10040547.
3
Activation of α7 Nicotinic Acetylcholine Receptor Upregulates HLA-DR and Macrophage Receptors: Potential Role in Adaptive Immunity and in Preventing Immunosuppression.α7 型烟碱型乙酰胆碱受体的激活上调 HLA-DR 和巨噬细胞受体:在适应性免疫和预防免疫抑制中的潜在作用。
Biomolecules. 2020 Mar 27;10(4):507. doi: 10.3390/biom10040507.
4
Why Does Knocking Out NACHO, But Not RIC3, Completely Block Expression of α7 Nicotinic Receptors in Mouse Brain?为什么敲除 NACHO,但不敲除 RIC3,能完全阻断小鼠脑中 α7 烟碱型乙酰胆碱受体的表达?
Biomolecules. 2020 Mar 19;10(3):470. doi: 10.3390/biom10030470.
5
Current Advances in Allosteric Modulation of Muscarinic Receptors.当前乙酰胆堿能受体变构调节的研究进展。
Biomolecules. 2020 Feb 18;10(2):325. doi: 10.3390/biom10020325.
6
Arachidonoylcholine and Other Unsaturated Long-Chain Acylcholines Are Endogenous Modulators of the Acetylcholine Signaling System.花生四烯酰胆碱和其他不饱和长链酰基胆碱是乙酰胆碱信号系统的内源性调节剂。
Biomolecules. 2020 Feb 12;10(2):283. doi: 10.3390/biom10020283.
7
Different Effects of Nicotine and N-Stearoyl-ethanolamine on Episodic Memory and Brain Mitochondria of α7 Nicotinic Acetylcholine Receptor Knockout Mice.尼古丁和 N-硬脂酰基乙醇胺对 α7 烟碱型乙酰胆碱受体敲除小鼠情景记忆和脑线粒体的不同影响。
Biomolecules. 2020 Feb 3;10(2):226. doi: 10.3390/biom10020226.
8
Attenuation in Nicotinic Acetylcholine Receptor α9 and α10 Subunit Double Knock-Out Mice of Experimental Autoimmune Encephalomyelitis.实验性自身免疫性脑脊髓炎的烟碱型乙酰胆碱受体α9 和α10 亚单位双敲除小鼠中的衰减。
Biomolecules. 2019 Dec 4;9(12):827. doi: 10.3390/biom9120827.
9
Refined structure of the nicotinic acetylcholine receptor at 4A resolution.4埃分辨率下烟碱型乙酰胆碱受体的精细结构。
J Mol Biol. 2005 Mar 4;346(4):967-89. doi: 10.1016/j.jmb.2004.12.031. Epub 2005 Jan 25.
10
ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL.关于别构转变的本质:一个合理的模型。
J Mol Biol. 1965 May;12:88-118. doi: 10.1016/s0022-2836(65)80285-6.

乙酰胆碱和乙酰胆碱受体:教科书知识和新数据。

Acetylcholine and Acetylcholine Receptors: Textbook Knowledge and New Data.

机构信息

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.

出版信息

Biomolecules. 2020 Jun 3;10(6):852. doi: 10.3390/biom10060852.

DOI:10.3390/biom10060852
PMID:32503306
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7355751/
Abstract

It was a pleasure to receive a proposal to organize and be a guest editor of a Special Issue ofBiomolecules. This is the field in which I am working and personally know some of the leadingscientists. My narrow field is the research on the peptide and protein neurotoxins from animalvenoms and their application as sophisticated tools for analysis of nicotinic acetylcholine receptors(nAChRs) [...].

摘要

很高兴收到组织并担任生物分子特刊客座编辑的提案。这是我正在研究的领域,我个人认识一些领先的科学家。我的研究领域很窄,主要研究来自动物毒液的肽和蛋白神经毒素及其作为分析烟碱型乙酰胆碱受体 (nAChRs) 的复杂工具的应用 [...]。