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基于聚[低聚(乙二醇)甲基丙烯酸酯] - 聚[(乙烯基苄基三甲基氯化铵)]的多功能杂化纳米结构，其包裹着磁性纳米颗粒和DNA。

Poly[oligo(ethylene glycol) methacrylate]--poly[(vinyl benzyl trimethylammonium chloride)] Based Multifunctional Hybrid Nanostructures Encapsulating Magnetic Nanoparticles and DNA.

作者信息

Chroni Angeliki, Forys Aleksander, Trzebicka Barbara, Alemayehu Adam, Tyrpekl Vaclav, Pispas Stergios

机构信息

Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 11635 Athens, Greece.

Centre of Polymer and Carbon Materials, Polish Academy of Sciences, 34 ul. M. Curie-Skłodowskiej, 41-819 Zabrze, Poland.

出版信息

Polymers (Basel). 2020 Jun 3;12(6):1283. doi: 10.3390/polym12061283.

DOI:10.3390/polym12061283
PMID:32503350
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7362237/
Abstract

We report on the preparation of novel and multifunctional hybrid spherical-shaped nanostructures involving a double-hydrophilic block copolymer, namely the neutral cationic poly[oligo(ethylene glycol) methacrylate]--poly[(vinyl benzyl trimethylammonium chloride)] (POEGMA--PVBTMAC) diblock copolymer, initially complexed with hydrophilic anionic magnetic nanoparticles (MNPs), and subsequently, with short deoxyribonucleic acid (113 bases DNA). The POEGMA--PVBTMAC copolymer, the copolymer/MNPs and the copolymer/MNPs/DNA tricomponent hybrid electrostatic complexes were studied by dynamic/electrophoretic light scattering (DLS/ELS) and cryogenic transmission electron microscopy (cryo-TEM) techniques for the determination of their structure and solution properties. The MNPs were complexed efficiently with the oppositely charged diblock chains, leading to well-defined hybrid organic-inorganic spherical-shaped nanostructures. A significant aggregation tendency of the MNPs is noticed in cryo-TEM measurements after the electrostatic complexation of DNA, implying an accumulation of the DNA macromolecules on the surface of the hybrid tricomponent complexes. Magnetophoretic experiments verified that the MNPs maintain their magnetic properties after the complexation initially with the copolymer, and subsequently, within the block polyelectrolyte/MNPs/DNA nanostructures.

摘要

我们报道了新型多功能杂化球形纳米结构的制备，该结构涉及一种双亲水嵌段共聚物，即中性阳离子聚[聚（乙二醇）甲基丙烯酸酯] - 聚[（乙烯基苄基三甲基氯化铵）]（POEGMA - PVBTMAC）二嵌段共聚物，其最初与亲水性阴离子磁性纳米颗粒（MNP）复合，随后与短脱氧核糖核酸（113个碱基的DNA）复合。通过动态/电泳光散射（DLS/ELS）和低温透射电子显微镜（cryo-TEM）技术研究了POEGMA - PVBTMAC共聚物、共聚物/MNP和共聚物/MNP/DNA三组分杂化静电复合物，以确定它们的结构和溶液性质。MNP与带相反电荷的二嵌段链有效复合，形成了明确的杂化有机-无机球形纳米结构。在DNA静电复合后，cryo-TEM测量中观察到MNP有明显的聚集趋势，这意味着DNA大分子在杂化三组分复合物表面的积累。磁泳实验证实，MNP在最初与共聚物复合后，以及随后在嵌段聚电解质/MNP/DNA纳米结构中仍保持其磁性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5932/7362237/1e2b8509b822/polymers-12-01283-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5932/7362237/feba37f32ea5/polymers-12-01283-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5932/7362237/f28594a95406/polymers-12-01283-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5932/7362237/e09ad93efe01/polymers-12-01283-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5932/7362237/38696e2e8905/polymers-12-01283-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5932/7362237/f0a308b4ad8c/polymers-12-01283-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5932/7362237/39f8716f3cb6/polymers-12-01283-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5932/7362237/29d7c211ff2a/polymers-12-01283-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5932/7362237/6e85886db7aa/polymers-12-01283-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5932/7362237/f22fd024cbe2/polymers-12-01283-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5932/7362237/74fd2bcddf77/polymers-12-01283-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5932/7362237/5914d564972c/polymers-12-01283-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5932/7362237/364691fc7b44/polymers-12-01283-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5932/7362237/1e2b8509b822/polymers-12-01283-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5932/7362237/feba37f32ea5/polymers-12-01283-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5932/7362237/f28594a95406/polymers-12-01283-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5932/7362237/e09ad93efe01/polymers-12-01283-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5932/7362237/38696e2e8905/polymers-12-01283-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5932/7362237/f0a308b4ad8c/polymers-12-01283-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5932/7362237/39f8716f3cb6/polymers-12-01283-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5932/7362237/29d7c211ff2a/polymers-12-01283-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5932/7362237/6e85886db7aa/polymers-12-01283-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5932/7362237/f22fd024cbe2/polymers-12-01283-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5932/7362237/74fd2bcddf77/polymers-12-01283-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5932/7362237/5914d564972c/polymers-12-01283-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5932/7362237/364691fc7b44/polymers-12-01283-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5932/7362237/1e2b8509b822/polymers-12-01283-g012.jpg

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PLMA-b-POEGMA Amphiphilic Block Copolymers as Nanocarriers for the Encapsulation of Magnetic Nanoparticles and Indomethacin.

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