Wadajkar Aniket S, Menon Jyothi U, Kadapure Tejaswi, Tran Richard T, Yang Jian, Nguyen Kytai T
Department of Bioengineering, The University of Texas at Arlington, Arlington, TX 76019 ; Joint Biomedical Engineering Program between The University of Texas at Arlington and The University of Texas Southwestern Medical Center, Dallas, TX 75390.
Recent Pat Biomed Eng. 2013 Apr 1;6(1):47-57. doi: 10.2174/1874764711306010007.
Recently, magnetic-based theranostic nanoparticle (MBTN) systems have been studied, researched, and applied extensively to detect and treat various diseases including cancer. Theranostic nanoparticles are advantageous in that the diagnosis and treatment of a disease can be performed in a single setting using combinational strategies of targeting, imaging, and/or therapy. Of these theranostic strategies, magnetic-based systems containing magnetic nanoparticles (MNPs) have gained popularity because of their unique ability to be used in magnetic resonance imaging, magnetic targeting, hyperthermia, and controlled drug release. To increase their effectiveness, MNPs have been decorated with a wide variety of materials to improve their biocompatibility, carry therapeutic payloads, encapsulate/bind imaging agents, and provide functional groups for conjugation of biomolecules that provide receptor-mediated targeting of the disease. This review summarizes recent patents involving various polymer coatings, imaging agents, therapeutic agents, targeting mechanisms, and applications along with the major requirements and challenges faced in using MBTN for disease management.
最近，基于磁性的诊疗纳米颗粒（MBTN）系统已得到广泛研究、探索并应用于包括癌症在内的各种疾病的检测和治疗。诊疗纳米颗粒的优势在于，利用靶向、成像和/或治疗的组合策略，可在单一环境中对疾病进行诊断和治疗。在这些诊疗策略中，包含磁性纳米颗粒（MNP）的基于磁性的系统因其在磁共振成像、磁性靶向、热疗和可控药物释放方面的独特应用能力而受到欢迎。为提高其有效性，MNP已用多种材料进行修饰，以改善其生物相容性、携带治疗载荷、封装/结合成像剂，并为生物分子的缀合提供官能团，从而实现对疾病的受体介导靶向。本综述总结了近期涉及各种聚合物涂层、成像剂、治疗剂、靶向机制和应用的专利，以及使用MBTN进行疾病管理时面临的主要要求和挑战。
