Oladipo Olusola Olalekan, Ayo Joseph Olusegun, Ambali Suleiman Folorunsho, Mohammed Bisalla, Aluwong Tanang
Biochemistry Division, National Veterinary Research Institute, P.M.B. 01, Vom, Nigeria; Department of Veterinary Pharmacology & Toxicology, Ahmadu Bello University, Zaria, Nigeria.
Department of Veterinary Physiology, Ahmadu Bello University, Zaria, Nigeria.
Environ Toxicol Pharmacol. 2017 Jul;53:199-205. doi: 10.1016/j.etap.2017.06.017. Epub 2017 Jun 22.
Lead (Pb), cadmium (Cd) and manganese (Mn) have many potential adverse health effects in vitro and in animal models of clinical toxicity. The current study investigated the dyslipidaemic and oxidative stress effects of chronic low-dose oral exposure to Pb, Cd and Mn and the combination (Pb+Cd+Mn) in rats for 15 weeks. Chronic exposure to the metals did not significantly (P>0.05) alter serum lipid profiles. However, the atherogenic index decreased by 32.2% in the Pb+Cd+Mn group, relative to the control. The triglyceride/high-density lipoprotein cholesterol ratio decreased by 39.4% in the Pb+Cd+Mn group, relative to the control, and elevated by 81.8, 94.8 and 20.8%, relative to the Pb, Cd and Mn groups, respectively. While the serum concentrations of malondialdehyde significantly increased in the Mn and Pb+Cd+Mn groups, that of glutathione peroxidase-1 decreased in the Pb+Cd+Mn group, and metallothionein-1 and zinc concentrations markedly decreased in all the metal treatment groups. The results suggest that long-term exposure of rats to Pb+Cd+Mn may result in hypolipidaemia, mediated via oxidative stress and metal interactions. Individuals who are constantly exposed to environmentally relevant levels of the metals may be at risk of hypolipidaemia.
铅（Pb）、镉（Cd）和锰（Mn）在体外及临床毒性动物模型中具有许多潜在的不良健康影响。本研究调查了大鼠经口长期低剂量暴露于Pb、Cd、Mn及其组合（Pb+Cd+Mn）15周后的血脂异常和氧化应激效应。长期暴露于这些金属并未显著（P>0.05）改变血清脂质谱。然而，与对照组相比，Pb+Cd+Mn组的动脉粥样硬化指数下降了32.2%。与对照组相比，Pb+Cd+Mn组的甘油三酯/高密度脂蛋白胆固醇比值下降了39.4%，与Pb、Cd和Mn组相比，分别升高了81.8%、94.8%和20.8%。虽然Mn组和Pb+Cd+Mn组的血清丙二醛浓度显著升高，Pb+Cd+Mn组的谷胱甘肽过氧化物酶-1浓度降低，且所有金属处理组的金属硫蛋白-1和锌浓度均显著降低。结果表明，大鼠长期暴露于Pb+Cd+Mn可能通过氧化应激和金属相互作用导致血脂过低。持续暴露于环境相关水平这些金属的个体可能有血脂过低的风险。
