Inhibition of postpyrogenic increase of phagocytic and killing activity of neutrophils by nonsteroid antiinflammatory drugs.

Acetylsalicylic acid (300 mg/kg), mefenamic acid (30 mg/kg) or indomethacin (20 mg/kg) given orally in the doses preventing the postpyrogenic fever, inhibited the stimulatory effect of LPS on phagocytic and killing activity of neutrophils. The dose of acetylsalicylic acid that did not eliminate fever in rabbits (100 mg/kg), had no suppressive effect upon fever-stimulated killing activity of neutrophils. The drugs administered twice a day to normothermic animals did not evoke any suppressive changes in the activity of neutrophils.