Migration of isolated rabbit lymphocytes in the course of pharmacological inhibition of pyrogenic fever.

The studies concerned in vitro migration of peripheral blood lymphocytes of rabbits given intravenously one dose of E. coli lipopolysaccharide (LPS) and antipyretic doses of acetylsalicylic acid (ASA), indomethacin (IND) or mefenamic acid (MEFA). In normothermic animals, ASA appeared to inhibit in vitro the spontaneous migration of lymphocytes. Contrary to ASA, MEFA and IND did not produce any significant changes in lymphocytes migration. Four hours after pyrogen injection migration of lymphocytes was slightly enhanced and after 24 h it was significantly inhibited. All non-steroid anti-inflammatory drugs examined counteracted this effect.