Debowy J, Obmińska-Domoradzka B, Switała M, Garbuliński T
Arch Immunol Ther Exp (Warsz). 1985;33(6):755-61.
The studies concerned in vitro migration of peripheral blood lymphocytes of rabbits given intravenously one dose of E. coli lipopolysaccharide (LPS) and antipyretic doses of acetylsalicylic acid (ASA), indomethacin (IND) or mefenamic acid (MEFA). In normothermic animals, ASA appeared to inhibit in vitro the spontaneous migration of lymphocytes. Contrary to ASA, MEFA and IND did not produce any significant changes in lymphocytes migration. Four hours after pyrogen injection migration of lymphocytes was slightly enhanced and after 24 h it was significantly inhibited. All non-steroid anti-inflammatory drugs examined counteracted this effect.
这些研究关注静脉注射一剂大肠杆菌脂多糖（LPS）以及解热剂量的乙酰水杨酸（ASA）、吲哚美辛（IND）或甲芬那酸（MEFA）后家兔外周血淋巴细胞的体外迁移情况。在体温正常的动物中，ASA似乎在体外抑制淋巴细胞的自发迁移。与ASA相反，MEFA和IND对淋巴细胞迁移未产生任何显著变化。注射热原4小时后淋巴细胞迁移略有增强，24小时后则受到显著抑制。所有检测的非甾体抗炎药都抵消了这种效应。
