Department of Neurosurgery, University Medical Center Groningen, Groningen, The Netherlands
Engineering and Technology Institute Groningen, Faculty of Science & Engineering, University of Groningen, Groningen, The Netherlands.
BMJ Open. 2020 Jun 4;10(6):e036404. doi: 10.1136/bmjopen-2019-036404.
We developed a zero-dimensional (0D) model to assess the patient-specific haemodynamics in the circle of Willis (CoW). Similar numerical models for simulating the cerebral blood flow (CBF) had only been validated qualitatively in healthy volunteers by magnetic resonance (MR) angiography and transcranial Doppler (TCD). This study aims to validate whether a numerical model can simulate patient-specific blood flow in the CoW under pathological conditions.
This study is a diagnostic accuracy study. We aim to collect data from a previously performed prospective study that involved patients with aneurysmal subarachnoid haemorrhage (aSAH) receiving both TCD and brain Computerd Tomography angiography (CTA) at the same day. The cerebral flow velocities are calculated by the 0D model, based on the vessel diameters measured on the CTA of each patient. In this study, TCD is considered the gold standard for measuring flow velocity in the CoW. The agreement will be analysed using Pearson correlation coefficients.
This study protocol has been approved by the Medical Ethics Review Board of the University Medical Center Groningen: METc2019/103. The results will be submitted to an international scientific journal for peer-reviewed publication.
NL8114.
我们开发了一个零维（0D）模型，以评估 Willis 环（CoW）中患者特定的血液动力学。类似的用于模拟脑血流（CBF）的数值模型仅通过磁共振（MR）血管造影和经颅多普勒（TCD）在健康志愿者中进行了定性验证。本研究旨在验证数值模型是否可以在病理情况下模拟 CoW 中的患者特定血流。
本研究是一项诊断准确性研究。我们旨在从先前进行的前瞻性研究中收集数据，该研究涉及同一天接受 TCD 和脑计算机断层血管造影（CTA）的动脉瘤性蛛网膜下腔出血（aSAH）患者。0D 模型根据每位患者的 CTA 测量的血管直径计算脑血流速度。在这项研究中，TCD 被认为是测量 CoW 中血流速度的金标准。将使用 Pearson 相关系数分析一致性。
本研究方案已获得格罗宁根大学医学中心医学伦理审查委员会的批准：METc2019/103。研究结果将提交给国际科学期刊进行同行评审发表。
NL8114。
