Israel Center for Disease Control, Israel Ministry of Health, Gertner Institute, Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel; Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine Tel Aviv University, Tel Aviv, Israel.
Israel Center for Disease Control, Israel Ministry of Health, Gertner Institute, Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel.
J Infect. 2020 Aug;81(2):297-303. doi: 10.1016/j.jinf.2020.05.078. Epub 2020 Jun 3.
Respiratory Syncytial Virus (RSV) is a known cause of morbidity among young children, while RSV-related disease in the elderly is not fully recognized. Several RSV candidate vaccines for infants, pregnant women and adults are under development. We aimed to estimate nationwide age-specific hospitalizations and seasonal trends, to help determine the optimal age for vaccination.
Hospitalizations with a primary RSV-related diagnoses were retrieved from the National Hospital Database for the years 2000-2017. Data were analyzed by year, month and age group to determine hospitalization rates and seasonal trends.
During the analysis period, 39,156 hospitalizations received primary RSV-related ICD-9 diagnostic codes. The highest mean yearly hospitalization rate occurred among infants <1 year of life (1,218.4 per 100,000). Within the first year of life, the highest mean yearly hospitalization rate was observed in the second month of life (3,541.5 hospitalizations per 100,000). Hospitalization rates for individuals ≥5 years old increased during the study period, primarily among patients ≥65 years of age, reaching hospitalization rate of 9 per 100,000 in 2017. A clear seasonal pattern was observed.
An effective vaccine for infants and pregnant women has the potential to reduce hospitalizations burden. RSV-related hospitalizations burden among adults requires additional research.
呼吸道合胞病毒（RSV）是导致幼儿发病的已知原因，而老年人的 RSV 相关疾病尚未得到充分认识。目前正在开发几种针对婴儿、孕妇和成人的 RSV 候选疫苗。我们旨在估计全国范围内特定年龄的住院率和季节性趋势，以帮助确定最佳接种年龄。
从 2000 年至 2017 年的国家医院数据库中检索出与 RSV 相关的主要诊断的住院数据。通过年份、月份和年龄组分析数据，以确定住院率和季节性趋势。
在分析期间，有 39156 例住院患者接受了与 RSV 相关的 ICD-9 主要诊断代码。婴儿（<1 岁）的年平均住院率最高（每 10 万人中有 1218.4 例）。在生命的第一年中，第二个月的年平均住院率最高（每 10 万人中有 3541.5 例住院）。≥5 岁人群的住院率在研究期间有所增加，主要是≥65 岁的患者，2017 年达到每 10 万人 9 例的住院率。观察到明显的季节性模式。
针对婴儿和孕妇的有效疫苗有可能减轻住院负担。成人与 RSV 相关的住院负担需要进一步研究。
