Division of Cardiology, Department of Medicine, Medical University of South Carolina, and Research Service, Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC 29425, USA.
Department of Biomedical Engineering, University of Virginia, 415 Lane Road, Charlottesville, VA 22903, USA.
Matrix Biol. 2020 Sep;91-92:1-7. doi: 10.1016/j.matbio.2020.05.006. Epub 2020 Jun 3.
Extracellular matrix (ECM) is the foundation on which all cells and organs converge to orchestrate normal physiological functions. In the setting of pathology, the ECM is modified to incorporate additional roles, with modifications including turnover of existing ECM and deposition of new ECM. The fibroblast is center stage in coordinating both normal tissue homeostasis and response to disease. Understanding how fibroblasts work under normal conditions and are activated in response to injury or stress will provide mechanistic insight that triggers discovery of new therapeutic treatments for a wide range of disease. We highlight here fibroblast roles in the cancer, lung, and heart as example systems where fibroblasts are major contributors to homeostasis and pathology.
细胞外基质（ECM）是所有细胞和器官汇聚的基础，以协调正常的生理功能。在病理条件下，ECM 会发生修饰，以纳入额外的角色，修饰包括现有 ECM 的更替和新 ECM 的沉积。成纤维细胞在协调正常组织稳态和对疾病的反应中处于中心地位。了解成纤维细胞在正常条件下如何工作以及如何在受到损伤或应激时被激活，将为发现广泛疾病的新治疗方法提供机制上的深入了解。在这里，我们重点介绍成纤维细胞在癌症、肺部和心脏中的作用，这些系统中成纤维细胞是维持稳态和发生病变的主要贡献者。
